头针联合六字诀对脑卒中后认知功能障碍患者认知功能、事件相关电位P300及血清NPAS4水平的影响  

Impact of scalp acupuncture combined with six-character formula on cognitive function,event related potential P300 and serum NPAS4 level in patients with cognitive impairment after stroke

作　　者：宋裕如 杨帅 齐明 潘维花 SONG Yuru;YANG Shuai;QI Ming;PAN Weihua(Department of Rehabilitation Medicine,Daxing District Integrated Traditional Chinese and Western Medicine Hospital,Beijing 100076,China)

机构地区：[1]北京市大兴区中西医结合医院康复医学科,北京100076

出　　处：《检验医学与临床》2025年第6期742-746,共5页Laboratory Medicine and Clinic

基　　金：国家自然科学基金项目(82105023)。

摘　　要：目的分析头针联合六字诀对脑卒中后认知功能障碍患者认知功能、事件相关电位P300及血清神经元PAS结构域蛋白4(NPAS4)水平的影响。方法选取2022年1月至2023年1月该院收治的脑卒中后认知功能障碍患者80例作为研究对象,采用随机数字表法将其分为对照组和试验组,每组40例。对照组采用常规西药联合头针治疗,试验组在对照组基础上增加六字诀训练,2组均连续治疗6周。对比分析2组临床疗效。观察2组治疗前、后患者蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力量表(ADL)评分、时间相关电位P300潜伏期和波幅及血清NPAS4、神经元特异性烯醇化酶(NSE)、脑源性神经生长因子(BDNF)水平。结果治疗后,试验组MoCA评分[27(25,30)分]、ADL评分[56(51,60)分]高于对照组[25(24,27)分、50(46,55)分],差异均有统计学意义(P<0.05)。治疗后,试验组P300潜伏期[(332.28±36.77)ms]明显短于对照组[(357.71±40.31)ms],P300波幅[(5.88±1.17)μV]明显高于对照组[(5.13±1.28)μV],差异均有统计学意义(P<0.05)。治疗后,试验组血清NPAS4[(1.91±0.67)μg/mL]、NSE水平[(9.15±1.23)μg/L]明显低于对照组[(2.32±0.62)μg/mL、(9.86±1.42)μg/L],血清BDNF水平[(5.23±1.03)μg/mL]高于对照组[(4.64±0.94)μg/mL],差异均有统计学意义(P<0.05)。试验组治疗总有效率为90.00%,明显高于对照组的70.00%,差异有统计学意义(P<0.05)。结论头针联合六字诀治疗脑卒中后认知功能障碍疗效显著,可增强脑认知处理信息能力,有效改善患者认知功能障碍。Objective To analyze the impact of scalp acupuncture combined with six-character formula on cognitive function,event related potential P300 and serum neuronal PAS domain protein 4(NPAS4)level in patients with cognitive impairment after stroke.Methods Eighty patients with stroke cognitive impairment who were treated in the hospital from January 2022 to January 2023 were selected as the study subjects,which were divided into control group and test group by the randomized numerical table method,with 40 patients in each group.The control group was treated with routine Western medicine combined with scalp acupuncture,while the test group was treated with six-character formula training on the basis of the control group,and both groups were treated continuously for 6 weeks.The clinical treatment effects of two groups were compared and analyzed.The Montreal Cognitive Assessment Scale(MoCA)scores,Activities of Daily Living(ADL)scores,event related potential P300 latency and wave amplitude,as well as serum NPAS4,neuron-specific enolase(NSE)and brain derived nerve growth factor(BDNF)levels of the patients in the two groups before and after treatment were observed.Results After treatment,the MoCA score[27(25,30)points]and ADL score[56(51,60)points]in the test group were higher than those in the control group[25(24,27)points,50(46,55)points],and the differences were statistically significant(P<0.05).After treatment,the P300 latency[(332.28±36.77)ms]in the test group was obviously shorter than that in the control group[(357.71±40.31)ms],the P300 amplitude[(5.88±1.17)μV]was obviously higher than that in the control group[(5.13±1.28)μV],and the differences were statistically significant(P<0.05).After treatment,the levels of serum NPAS4[(1.91±0.67)μg/mL]and NSE[(9.15±1.23)μg/L]in the test group were obviously lower than those in the control group[(2.32±0.62)μg/mL,(9.86±1.42)μg/L],while the level of serum BDNF[(5.23±1.03)μg/mL]was higher than that in the control group[(4.64±0.94)μg/mL],and the differences were st

关 键 词：脑卒中 认知功能障碍 头针 六字诀 事件相关电位P300 神经元PAS结构域蛋白4 神经元特异性烯醇化酶 脑源性神经生长因子 

分 类 号：R255.2[医药卫生—中医内科学] R743.3[医药卫生—中医学]