解毒生肌膏联合凡士林纱布对促进肛瘘术后创面愈合的疗效及对血清炎症因子和生长因子水平的影响  

Effect of Jiedu Shengji ointment combined with Vaseline gauze on promoting wound healing after anal fistula operation and serum levels of inflammatory factors and growth factors

作　　者：卢毅 张欣[1] 成士超 韩亚珠 LU Yi;ZHANG Xin;CHENG Shichao;HAN Yazhu(Department of Surgery,Baoding First Central Hospital,Baoding,Hebei 071000,China)

机构地区：[1]河北省保定市第一中心医院外科,河北保定071000

出　　处：《检验医学与临床》2025年第6期815-820,共6页Laboratory Medicine and Clinic

基　　金：河北省保定市科技计划项目(2241ZF237)。

摘　　要：目的探讨解毒生肌膏联合凡士林纱布促肛瘘术后创面愈合的临床疗效,以及对肛瘘患者血清炎症因子和生长因子水平的影响。方法选择2023年1-12月在该院行手术治疗的122例肛瘘患者作为研究对象,根据术后创面治疗方式的不同将其分为观察组和对照组,每组61例。观察组采用解毒生肌膏联合凡士林纱布换药进行治疗,对照组采用凡士林纱布换药进行治疗,2组均连续治疗4周。对比分析2组的疗效。对比2组治疗前、后对创面肿胀、疼痛、渗出及肉芽组织评分。统计分析治疗1、2、3、4周时2组患者的创面愈合率。对比2组治疗前、后血清炎症因子[血清淀粉样蛋白A(SAA)、白细胞介素(IL)-6、降钙素原(PCT)]和生长因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、血小板衍生生长因子(PDGF)]水平。统计2组不良反应发生情况。结果观察组总有效率为100.00%(61/61),明显高于对照组的93.44%(57/61),差异有统计学意义(P<0.05)。治疗后,2组创面肿胀、疼痛、渗出评分明显低于治疗前,差异均有统计学意义(P<0.05);治疗后,观察组创面肿胀、疼痛、渗出及肉芽组织评分明显低于对照组,差异均有统计学意义(P<0.05)。重复测量方差分析结果显示,2组创面愈合率的组间效应、时间效应和交互效应差异均有统计学意义(P<0.05)。单因素重复测量方差分析结果显示,与治疗1周比较,观察组和对照组治疗2、3、4周的创面愈合率均明显升高(P<0.05)。多变量方差分析结果显示,观察组治疗1、2、3、4周的创面愈合率均显著高于对照组(P<0.05)。治疗后,2组血清SAA、IL-6、PCT水平明显低于治疗前,且观察组血清SAA、IL-6、PCT水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清VEGF、bFGF、PDGF水平明显高于治疗前,且观察组血清VEGF、bFGF、PDGF水平明显高于对照组,差异均有统计学意义(P<0.05)。治疗过�Objective To investigate the clinical effect of Jiedu Shengji ointment combined with Vaseline gauze to promote wound healing after anal fistula operation,and the effect on serum levels of inflammatory factors and growth factors in patients with anal fistula.Methods A total of 122 patients with anal fistula who underwent surgical treatment in the hospital from January to December 2023 were selected as the study objects,which were divided into observation group and control group according to different postoperative wound treatment methods,61 cases in each group.The observation group was treated with Jiedu Shengji ointment combined with Vaseline gauze dressing change,and the control group was treated with Vaseline gauze dressing change.Both groups were treated continuously for 4 weeks.The efficacy of the two groups was compared and analyzed.The wound swelling,pain,exudation and granulation tissue scores were compared between the two groups before and after treatment.The wound healing rates of the two groups were statistically analyzed after 1,2,3 and 4 weeks of treatment.The levels of serum inflammatory factors[serum amyloid A(SAA),interleukin(IL)-6,procalcitonin(PCT)]and growth factors[vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF)]were compared between the two groups before and after treatment.The adverse reactions of the two groups were analyzed.Results The total effective rate of the observation group was 100.00%(61/61),which was significantly higher than 93.44%(57/61)of the control group,and the difference was statistically significant(P<0.05).After treatment,the wound swelling,pain and exudation scores of the two groups were significantly lower than those before treatment,with statistically significant differences(P<0.05).After treatment,wound swelling,pain,exudation and granulation tissue scores in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Repeated measure

关 键 词：解毒生肌膏 凡士林纱布 肛瘘 炎症因子 生长因子 

分 类 号：R657.16[医药卫生—外科学] R266[医药卫生—临床医学]