IgA肾病患者FABP1和FABP4水平与疾病活动性的关系  

Relationship of FABP1 and FABP4 levels with disease activity in patients with IgA nephropathy

作　　者：苏宇[1] 张健[1] 宋晓英[1] SU Yu;ZHANG Jian;SONG Xiaoying(Department of Nephrology,Chengdu Second People′s Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]四川省成都市第二人民医院肾病内科,四川成都610000

出　　处：《检验医学与临床》2025年第6期845-849,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨免疫球蛋白A(IgA)肾病患者脂肪酸结合蛋白1(FABP1)和脂肪酸结合蛋白4(FABP4)水平与疾病活动性的相关性。方法选取2018年3月至2021年9月该院收治的IgA肾病患者240例作为观察组,另选取同期在该院体检健康的志愿者240例作为对照组。对比2组研究对象的收缩压、舒张压、24 h尿蛋白定量(24 h UTP)、肾小球滤过率(eGFR)和血肌酐(Scr)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)和血浆清蛋白(ALB)、FABP1、FABP4、IgA和补体C3(C3)水平。采用Pearson相关分析观察组血清FABP1、FABP4水平与IgA、C3、Scr、ALB和收缩压、舒张压、24 h UTP、eGFR、TC、TG、HDL-C的相关性;采用多因素Logistic回归分析影响IgA肾病患者疾病活动性的因素。结果观察组血清FABP4、IgA、C3、TC、TG和Scr水平以及收缩压、舒张压、24 h UTP显著高于对照组,而FABP1、eGFR、ALB和HDL-C水平显著低于对照组,差异均有统计学意义(P<0.05)。依据肾内活动性指数得分将观察组患者分为高分组(得分≥7分)174例和低分组(得分<7分)66例;与低分组相比,高分组血清FABP4、IgA和C3水平明显升高,FABP1、ALB水平和eGFR明显降低,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,IgA肾病患者血清FABP1水平均与IgA、C3、Scr水平及收缩压、舒张压、24 h UTP、TC和TG呈负相关(P<0.05),与eGFR、HDL-C和ALB水平呈正相关(P<0.05);血清FABP4水平均与IgA、C3、Scr水平和收缩压、舒张压、24 h UTP、TC和TG呈正相关(P<0.05),与eGFR、HDL-C和ALB水平呈负相关(P<0.05)。多因素Logistic回归分析结果显示,血清FABP4、IgA、C3水平升高是影响IgA肾病患者疾病活动性的危险因素(P<0.05),血清FABP1和ALB水平升高及eGFR增大是影响IgA肾病患者疾病活动性的保护因素(P<0.05)。结论IgA肾病患者血清FABP1水平降低,FABP4水平升高,二者与IgA肾病患者疾病活动性关系密切�Objective To explore the correlation of the levels of fatty acid binding protein 1(FABP1)and fatty acid binding protein 4(FABP4)with disease activity in patients with immunoglobulin A(IgA)nephropathy.Methods A total of 240 patients with IgA nephropathy admitted to the hospital from March 2018 to September 2021 were selected as the observation group,and another 240 healthy volunteers who underwent physical examinations at the hospital during the same period were selected as the control group.The systolic blood pressure,diastolic blood pressure,24 h urinary protein quantification(24 h UTP),estimated glomerular filtration rate(eGFR),serum creatinine(Scr),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglycerides(TG),as well as plasma albumin(ALB),FABP1,FABP4,IgA and complement C3(C3)between the two groups were compared.Pearson correlation analysis was used to observe the correlation of serum FABP1 and FABP4 levels with IgA,C3,Scr,ALB,as well as systolic and diastolic blood pressure,24 h UTP,eGFR,TC,TG and HDL-C.Multivariate Logistic regression analysis was used to investigate the factors affecting disease activity in patients with IgA nephropathy.Results The serum levels of serum FABP4,IgA,C3,TC,TG and Scr,as well as systolic blood pressure,diastolic blood pressure and 24 h UTP,in the observation group were significantly higher than those in the control group,while FABP1,eGFR,ALB and HDL-C levels were significantly lower in the control group,and the differences were statistically significant(P<0.05).According to the renal activity index score,patients in the observation group were divided into high score group(≥7 points)with 174 cases and low score group(<7 points)with 66 cases;compared with the low score group,the serum levels of FABP4,IgA and C3 were significantly increased in the high score group,while FABP1,ALB levels and eGFR were significantly decreased,and the differences were statistically significant(P<0.05).The Pearson correlation analysis r

关 键 词：IGA肾病 脂肪酸结合蛋白1 脂肪酸结合蛋白4 疾病活动性 

分 类 号：R692.31[医药卫生—泌尿科学]