心脉隆注射液联合呋塞米治疗心力衰竭的疗效  

Therapeutic Effect of Xinmailong Injection Combined with Furosemide in the Treatment of Heart Failure

作　　者：周圆圆 ZHOU Yuanyuan(Department of Geriatrics,Xuzhou Tongshan District Hospital of Traditional Chinese Medicine,Xuzhou 221000,Jiangsu,China)

机构地区：[1]徐州市铜山区中医院老年病科,江苏徐州221000

出　　处：《世界复合医学(中英文)》2024年第11期58-61,共4页World Journal of Complex Medicine

摘　　要：目的探讨心脉隆联合呋塞米治疗心力衰竭的疗效。方法选取2023年1—12月于徐州市铜山中医院老年病科进行治疗的98例心力衰竭患者,按照治疗方法的不同分为对照组(n=49,予呋塞米治疗),观察组(n=49,予呋塞米及心脉隆注治疗)。比较治疗后两组患者心功能指标、6 min步行试验距离、血清因子指标、治疗总有效率与不良反应发生率。结果治疗后,观察组6 min步行试验距离长于对照组,血清N末端脑钠肽前体、血浆内脑钠肽及乳酸水平均低于对照组,差异有统计学意义(P均<0.05)。治疗后,与对照组左室射血分数、左室舒张末期内径、左室收缩末期内径相比,观察组均更优,差异有统计学意义(P均<0.05)。两组患者心慌、胸闷、低血压发生率比较,差异无统计学意义(P>0.05)。观察组治疗总有效率为87.76%(43/49),高于对照组的71.43%(35/49),差异有统计学意义(χ^(2)=4.397,P<0.05)。结论心脉隆联合呋塞米可有效改善心力衰竭患者的临床症状,在提高临床疗效的同时仍具有安全性。Objective To investigate the efficacy of Xinmailong Injection combined with furosemide in the treatment of heart failure.Methods A total of 98 patients with heart failure who treated in the Department of Geriatrics of Xuzhou Tongshan District Hospital of Traditional Chinese Medicine from January to December 2023 were selected and divided into control group(n=49,treated with furosemide)and observation group(n=49,treated with furosemide and Xinmailong Injection)according to different treatment methods.The cardiac function indexes,6 min walking test distance,serum fouctor indexes,total effective rate of treatment and incidence of adverse reactions were compared between the two groups after treatment.Results After treatment,the distance of 6 min walking test in the observation group was longer than that in the control group,and the levels of serum N-terminal pro-brain natriuretic peptide,plasma brain natriuretic peptide and lactic acid were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,compared with the control group,the left ventricular ejection fraction,left ventricular end-diastolic diameter,and left ventricular end-systolic diameter were better in the observation group,and the difference was statistically significant(all P<0.05).There was no significant difference in the incidence of palpitation,chest tightness and hypotension between the two groups(P>0.05).The total effective rate of treatment in the observation group was 87.76%(43/49),which was higher than 71.43%(35/49)in the control group,and the difference was statistically significant(χ^(2)=4.397,P<0.05).Conclusion Xinmailong Injection combined with furosemide can improve the clinical symptoms of patients with heart failure effectively.They can improve clinical efficacy while still having safety.

关 键 词：心力衰竭 呋塞米 心脉隆注射液 

分 类 号：R54[医药卫生—心血管疾病]