囊胚不同扩张和孵化程度对薄型子宫内膜冻融胚胎移植患者临床结局的影响  

The efect of diferent degrees of blastocyst expansion and incubation on the clinical outcomes of patients ffwith thin endometrial freezethaw embryo transfer

作　　者：陈秋彤 候振 孙嘉博 臧鹏飞 杨旭 杨炜敏 CHEN Qiutong;HOU Zhen;SUN Jiabo;ZANG Pengfei;YANG Xu;YANG Weimin(Department of Reproductive Medicine,Hebei Maternity Hospital,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北生殖妇产医院生殖医学科,石家庄050000

出　　处：《中国性科学》2025年第3期62-66,共5页Chinese Journal of Human Sexuality

基　　金：石家庄市科技计划项目(221200533)。

摘　　要：目的 探讨囊胚不同扩张和孵化程度对薄型子宫内膜(TE)冻融胚胎移植患者临床结局的影响。方法 回顾性分析2020年1月至2022年3月河北生殖妇产医院收治的866例接受冻融周期单囊胚移植不孕症患者的临床资料,根据子宫内膜厚度分为正常组(n=580)和TE组(n=286)。比较两组妊娠结局、新生儿结局,以及囊胚不同扩张和孵化程度对TE组妊娠结局及新生儿结局的影响。结果 TE组早期流产率和晚期流产率高于正常组,活产率低于正常组(P<0.05)。TE组早产率高于正常组,出生正常体重率低于正常组(P<0.05);两组畸形率比较,差异无统计学意义(P>0.05)。与移植6期囊胚患者比较,移植4期和5期囊胚患者早期流产率、晚期流产率降低,活产率升高(P<0.05)。与移植6期囊胚患者比较,移植4期和5期囊胚患者新生儿早产率降低,新生儿出生正常体重率升高(P<0.05),畸形率差异无统计学意义(P>0.05)。结论 囊胚不同扩张和孵化程度可影响TE冻融胚胎移植患者妊娠结局及部分新生儿结局,移植扩张和孵化程度4、5期囊胚临床结局最佳。ObjectiveTo investigate the effect of different degrees of blastocyst expansion and incubation on clinical outcomes of patients with thin endometrium(TE)frozen-thawed embryo transfer.MethodsA retrospective analysis was conducted on the clinical data of 866 infertile patients who underwent single blastocyst transfer in frozen-thawed cycles in Hebei Maternity Hospital from January2020 to March 2022.The patients were divided into a normal group(n=580)and a TE group(n=286)based on endometrial thickness.The pregnancy outcomes,neonatal outcomes,and the effects of different degrees of blastocyst expansion and incubation on pregnaney and neonatal outcomes in the TE group were compared.Results The TE group had higher rates of early and late miscarriage and a lower live birth rate compared to the normal group(P<0.05).The TE group also had a higher preterm birth rate and a lower rate of normal birth weight compared to the normal group(P<0.05);there was no significant difference in the rate of malformations between the two groups(P>0.05).Compared to patients who transferred stage 6 blastocysts,those who transferred stage 4 and 5 blastocysts had lower rates of early and late miscarriage and a higher live birth rate(P<0.05).Compared to patients who transferred stage 6 blastocysts,those who transferred stage 4 and 5 blastocysts had a lower preterm birth rate and a higher rate of normal birth weight(P<0.05).with no significant difference in the rate of malformations(P>0.05).ConclusionsDifferent degrees of blastocyst expansion and incubation can affect pregnaney outcomes and some neonatal outcomes in TE patients undergoing frozen-thawed embryo transfer,with the transfer of stage 4 and 5 blastocysts yielding the best clinical outcomes.

关 键 词：薄型子宫内膜 囊胚分期 冻融胚胎移植 妊娠结局 新生儿结局 

分 类 号：R711[医药卫生—妇产科学]