微生物-肠-脑通讯对心脏骤停后脑损伤神经炎症的影响  

Impact of microbiota-gut-brain axis on neuroinflammation after post-cardiac arrest brain injury

作　　者：张浩峻 敬梅 朱雨锋 徐天鹏 陈羲 石容怡 单怡 ZHANG Haojun;JING Mei;ZHU Yufeng;XU Tianpeng;CHEN Xi;SHI Rongyi;SHAN Yi(Department of Emergency,Naval Medical Center,Shanghai 200052,Shanghai,China;不详)

机构地区：[1]海军特色医学中心急诊医学科,上海200052 [2]海军军医大学第二附属医院急诊与危重症医学科,上海200003

出　　处：《实用医学杂志》2025年第6期911-915,共5页The Journal of Practical Medicine

基　　金：科技部国家重大研发计划(编号:2022YFC3103-001004)。

摘　　要：心脏骤停是一个重大的公共卫生事件,对人类生命和健康构成重大威胁。心肺复苏后脑损伤是经历心脏骤停的患者最主要预后不良因素和死亡原因,目前治疗手段及效果有限,近年来随着对微生物-肠-脑通讯的深入研究,发现通过调节肠道微生物及其代谢产物可能对心脏骤停后脑损伤中神经炎症起到调控作用。微生物-肠-脑通讯的关键物质是短链脂肪酸,机制涉及免疫、内分泌、神经调节通路,通过补充产短链脂肪酸菌群或者短链脂肪酸,可以改善心肺复苏后肠道菌群紊乱,减轻神经炎症。短链脂肪酸作为微生物-肠-脑通讯中的关键介质对心脏骤停后脑损伤的治疗具有巨大的潜力。该综述探讨了微生物-肠-脑通讯通过免疫、内分泌、神经调节通路在心肺复苏后脑损伤神经炎症中的影响和调控机制,为心肺复苏后脑损伤的治疗提供一种新的思路。Cardiac arrest is a major health event that poses a major threat to human life and health.Postcardiac arrest brain injury is the main adverse prognostic factor and cause of death in patients who experience cardiac arrest.Currently,the therapeutic methods and effects are limited.In recent years,with the in-depth research on microbiota-gut-brain communication,it has been found that intestinal microbiota and their metabolites may play a role in the regulation of neuroinflammation in post-cardiac arrest brain injury.Short-chain fatty acids are the key substances in microbiota-gut-brain communication,and the mechanism involves immune,endocrine and neuroregulatory pathways.Supplementation of short-chain fatty acid-producing bacteria or short-chain fatty acids can improve intestinal flora disorder and reduce neuroinflammation after cardiopulmonary resuscitation.As a key mediator in microbial-gut-brain communication,short-chain fatty acids have great potential for the treatment of brain injury after cardiac arrest.This review explores the role and regulatory mechanism of microbiota-gut-brain communication in the neuroinflammation of brain injury after cardiopulmonary resuscitation through immune,endocrine and neuroregulatory pathways,providing a new idea for the treatment of post-cardiac arrest brain injury.

关 键 词：心脏骤停 心脏骤停后脑损伤 短链脂肪酸 微生物-肠-脑轴 

分 类 号：R459.9[医药卫生—治疗学]