银杏叶提取物冻干舌下片的制备  

Preparation of lyophilized sublingual tablets of ginkgo biloba extract

作　　者：宋嘉佳 李寒冰 李敏枫 檀世祖 王天舒 张昊然 蒋巧萍 宇泉霖 蔡程科[1] SONG Jia-jia;LI Han-bing;LI Min-feng;TAN Shi-zu;WANG Tian-shu;ZHANG Hao-ran;JIANG Qiao-ping;YU Quan-lin;CAI Cheng-ke(School of Chinese Meteria Medica,Beijng University of Chinese Medicine,Beijing 102488)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《中南药学》2025年第2期404-408,共5页Central South Pharmacy

摘　　要：目的建立银杏叶提取物冻干舌下片的制备方法及质量评价标准。方法通过星点设计-效应面法筛选银杏叶提取物冻干舌下片最优处方制备工艺。结果银杏叶提取物冻干舌下片最优处方为银杏叶提取物40 mg/片、普鲁兰多糖8.6 mg/片、氢氧化钠0.9 mg/片、黄原胶0.2 mg/片。结论银杏叶提取物冻干舌下片制备工艺稳定可靠,有效成分含量测定合格,可用于大规模生产。Objective To prepare and evaluate the quality of lyophilized sublingual tablets of ginkgo biloba extract.Methods The optimal prescription of lyophilized sublingual tablets of ginkgo biloba extract was screened by central composite design-response surface methodology.Results The optimal prescription for lyophilized sublingual tablets of ginkgo biloba extract included ginkgo biloba extract 40 mg/tablet,pullulan polysaccharide 8.6 mg/tablet,sodium hydroxide 0.9 mg/tablet,and xanthan gum 0.2 mg/tablet.Conclusion The preparation of lyophilized sublingual tablets of ginkgo biloba extract is stable and reliable,and the content of active components is qualified for large-scale production.

关 键 词：银杏叶提取物 冷冻干燥法 星点设计-效应面法 

分 类 号：R944[医药卫生—药剂学]