黄芪多糖在肺动脉高压治疗中的作用及机制研究进展  

Research progress in the effect and mechanism of astragalus polysaccharide for pulmonary hypertension

作　　者：周怡博 于淼 马丽娟[1] 祝田田 ZHOU Yi-bo;YU Miao;MA Li-juan;ZHU Tian-tian(Xinxiang Medical Institute,Xinxiang Henan 453003)

机构地区：[1]新乡医学院,河南新乡453003

出　　处：《中南药学》2025年第2期489-494,共6页Central South Pharmacy

基　　金：河南省自然科学基金面上项目(No.242300421305);河南省高等学校青年骨干教师培养计划(No.2024GGJS089)。

摘　　要：肺动脉高压是一种慢性进行性疾病,病死率高,具有肺血管阻力增加、肺血管重构、肺动脉压力升高的临床特点,可导致右心衰竭和死亡。黄芪多糖是黄芪发挥作用的主要成分,对多种疾病具有治疗作用,目前已有多项研究证明黄芪多糖对肺动脉高压具有保护作用,其作用机制与NO/sGC/cGMP、Calpain-1信号通路、KLF5/HIF-1α等多种通路有关。本文综述了黄芪多糖在肺动脉高压治疗中的作用及机制研究进展,以期为肺动脉高压的治疗提供参考。Pulmonary hypertension(PH)is a chronic disease,with a high mortality.PH is characterized by increased pulmonary vascular resistance and pulmonary artery pressure,and pulmonary vascular reconstruction,which may lead to right heart failure and death.Astragalus polysaccharide(APS)is the main component of astragalus,and has treatment effect on many diseases.At present,many studies have proved that APS has a protective effect on PH,whose mechanism of action is related to various pathways,including NO/sGC/cGMP,Calpain-1 signaling pathway,and KLF5/HIF-1α.This article summarized the research progress in the effect and mechanism of APS for PH to provide reference for the treatment of PH.

关 键 词：肺动脉高压 黄芪多糖 抗炎 抗血栓 

分 类 号：R286[医药卫生—中药学]