肠道微生物群与缺铁性贫血的因果关系:一项两样本孟德尔随机化研究  

Causal relationship between gut microbiota and iron deficiency anemia:a Mendelian randomization study of two-samples

作　　者：付楠 杨淦傑 张佳彤 王一[2] FU Nan;YANG Ganjie;ZHANG Jiatong;WANG Yi(Yan′an Medical College of Yan′an University,Yan′an 716000,China;Department of Hematology,Shaanxi Provincial People′s Hospital,Xi′an 710068,China)

机构地区：[1]延安大学延安医学院,陕西延安716000 [2]陕西省人民医院血液内科,陕西西安710068

出　　处：《延安大学学报(医学科学版)》2025年第1期44-52,共9页Journal of Yan'an University:Medical Science Edition

摘　　要：目的本研究旨在利用孟德尔随机化研究分析肠道微生物与缺铁性贫血(iron deficiency anemia,IDA)发病风险的因果关系。方法利用英国生物库GWAS数据库的公开数据集,以肠道菌群相关单核苷酸多态性位点作为工具变量。采取两样本孟德尔随机化方法,使用逆方差加权法、MR-Egger回归法、加权中位法等5种方法评价其因果关系,并进行质量控制。结果发现14个不同水平的肠道菌群可能与IDA的发生有潜在因果关系。经Benjamini-Hochberg(BH)法矫正之后,放线菌目、巴斯德氏菌目和梭菌目肠道微生物与IDA的发病之间的因果关系有统计学意义(P_(-BH)<0.05)。结论本研究发现放线菌目、巴斯德氏菌目和梭菌目肠道微生物与IDA的发病率呈负相关,为IDA治疗提供了新思路。Objective This study was to examine the causal relationship between the gut microbiota and the risk of developing iron deficiency anemia(IDA)through the use of a Mendelian randomization study.Methods The publicly available datasets from the United Kingdom Biobank genome-wide association study database were employed in this investigation.A two-sample Mendelian randomization method was employed,utilizing gut flora-associated single nucleotide polymorphism loci as instrumental variables.Five methods,such as inverse variance weighting method,MR-Egger regression method and weighted median method,were used to evaluate the causal relationship and carry out quality control.Results 14 different levels of intestinal flora that may have a potential causal relationship with the development of iron deficiency anemia were found.The causal relationship between Order.Actinomycetales,Order.Pasteurellales and Order.Clostridiales and the development of iron deficiency anemia was statistically significant after correction by the Benjamini-Hochberg method(P_(-BH)<0.05).Conclusion This study found that Order.Actinomycetales,Order.Pasteurellales,Order.Clostridiales were negatively correlated with the incidence of IDA,which provided novel insights for IDA treatment.

关 键 词：缺铁性贫血 孟德尔随机化 肠道微生物群 单核苷酸多态性位点 

分 类 号：R378[医药卫生—病原生物学]