Porous Ti_(3)SiC_(2)ceramics with improved osteogenic functions via biomineralization as load-bearing bone implants  

作　　者：Qian Xu Shuze Wang Yun Bai Qiang Wang Rui Yang Xiaohui Wang Xiaowu Li Xing Zhang 

机构地区：[1]Department of Materials Physics and Chemistry,School of Materials Science and Engineering,Key Laboratory for Anisotropy and Texture of Materials,Ministry of Education,Northeastern University,Shenyang 110819,China [2]Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China [3]School of Materials Science and Engineering,University of Science and Technology of China,Hefei 230026,China [4]Liaoning Provincial Key Laboratory of Oral Diseases,School and Hospital of Stomatology,China Medical University,Shenyang 110001,China

出　　处：《Journal of Materials Science & Technology》2024年第28期248-259,共12页材料科学技术(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.52273278);the Liaoning Revitalization Talents Program(No.XLYC2007112).

摘　　要：Ti_(3)SiC_(2)ceramics exhibit excellent mechanical properties and good biocompatibility,rendering them promising bone substitutes for load-bearing conditions.However,the bone integration and osteogenic ability of Ti_(3)SiC_(2)ceramics remain unclear.Herein,porous Ti_(3)SiC_(2)ceramics were prepared and systematically investigated as bone scaffolds.The Ti_(3)SiC_(2)scaffolds with a porosity of 62.9%±2.5%showed high compressive strength∼68.12±4.33 MPa.Silicon hydroxyl groups formed on the surface of Ti_(3)SiC_(2)after soaking in simulated body fluid,which played a critical role in the apatite mineralization of the scaffolds.Biomineralization of Ti_(3)SiC_(2)scaffolds was found when implanted subcutaneously in the rat dorsum for 2 weeks,demonstrating good osteogenesis ability.The apatite mineralization of the Ti_(3)SiC_(2)scaffold facilitated the polarization of RAW264.7 cells from M1 to M2 phenotype,which also promoted the differentiation of MC3T3-E1 cells.The porous Ti_(3)SiC_(2)scaffolds improved osteointegration and bone regeneration after implantation in rabbit femoral defects.Impressively,the number of the newly formed trabeculae in the Ti_(3)SiC_(2)group was three times of the control group after implantation for 8 weeks,showing excellent bone defect repair.This work demonstrates that Ti_(3)SiC_(2)implants with improved biological functions likely via in-situ biomineralization are promising candidates for bone regeneration.

关 键 词：Ti_(3)SiC_(2)scaffolds BIOMINERALIZATION Macrophage polarization Bone regeneration 

分 类 号：TQ1[化学工程]