3D-printing advances mass spectrometry in biomedical analysis  

作　　者：Wei Chen Bo-chao Zhang Magdalena M.Stevanovic Lin Huang Kun Qian 

机构地区：[1]State Key Laboratory of Systems Medicine for Cancer,School of Biomedical Engineering,Institute of Medical Robotics and Shanghai Academy of Experimental Medicine,Shanghai Jiao Tong University,Shanghai 200030,China [2]Group for Biomedical Engineering and Nanobiotechnology,Institute of Technical Sciences,Serbian Academy of Sciences and Arts,Kneza Mihaila 35/IV,Beograd 11000,Serbia [3]Department of Clinical Laboratory Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China [4]Institute of Thoracic Oncology,Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China

出　　处：《LabMed Discovery》2024年第1期19-31,共13页检验医学发现(英文)

基　　金：the National Key R&D Program of China(Nos.2021YFF0703500,2022YFE0103500);National Natural Science Funds(No.82372148);Medical-Engineering Joint Funds of Shanghai Jiao Tong University(Nos.YG2021ZD09,YG2022QN107 and YG2023ZD08);Shanghai Institutions of Higher Learning(No.2021-01-07-00-02-E00083);sponsored by the Innovative Research Team of High-Level Local Universities in Shanghai(No SHSMUZDCX20210700);Innovation Group Project of Shanghai Municipal Health Commission(2019CXJQ03);Innovation Research Plan by the Shanghai Municipal Education Commission(ZXWF082101);National Research Center for Translational Medicine Shanghai(Nos.TMSK-2021-124,NRCTM(SH)-2021-06);Medical-Engineering Joint Funds of University of Shanghai for Science and Technology(No.2023GD-XK01Z);Funds for the realization and financing of scientific research work of the Institute of Technical Sciences of SASA in 2024 provided by the Ministry of Science,Technological Development and Innovation(MoSTDI)of the Republic of Serbia(No.451-03-66/2024-03/200175).

摘　　要：Mass spectrometry(MS)is an analytical technique for molecular identification and characterization,with applications spanning various scientific disciplines.Despite its significance,MS faces challenges in widespread adoption due to cost constraints,instrument portability issues,and complex sample handling requirements.In recent years,3D printing has emerged as a technology across industries due to its cost-effectiveness,customization capabilities,and rapid prototyping features.This review explores the integration of 3D printing with MS technology to overcome existing limitations and enhance biomedical analysis capabilities.We first categorize mainstream 3D printing methods and assess their potential in MS applications.We also discuss their roles in different MS categories such as liquid chromatography mass spectrometry(LCMS),gas chromatography mass spectrometry(GCMS),ambient ionization mass spectrometry(AIMS),and matrix-assisted laser desorption/ionization MS(MALDI MS)in biomedical research.Additionally,we highlight the current challenges and future research directions for advancing 3D printing-assisted mass spectrometry,emphasizing its role in enabling portable,costeffective,and customized MS solutions for biomedical analysis.

关 键 词：3D-printing Mass spectrometry Liquid chromatography mass spectrometry (LCMS) Gas chromatograpgy(GCMS) Ambient ionization mass spectrometry(AIMS) 

分 类 号：O57[理学—粒子物理与原子核物理]