基于高分辨质谱的非靶向筛查技术在化妆品安全性风险物质监管中的应用前景  

Application Prospects of Non-Targeted Screening Technology Based on High-Resolution Mass Spectrometry in the Regulation of Safety Risk Substances in Cosmetics

作　　者：郭栋 梁静文 李杨杰[1] 尹胜[2] 方继辉[1] GUO Dong;LIANG Jing-wen;LI Yang-jie;YIN Sheng;FANG Ji-hui(Guangdong Institute for Drug Control;School of Pharmaceutical Sciences,Sun Yat-sen University)

机构地区：[1]广东省药品检验所 [2]中山大学药学院

出　　处：《中国食品药品监管》2025年第2期104-111,共8页China Food & Drug Administration Magazine

基　　金：广东省药品监督管理局2023年度科技创新项目(ZA20230069);广东省省级科技计划项目(2023A1111120025);广东省药品监督管理局2024年度科技创新项目(2024ZDZ04)。

摘　　要：化妆品中的安全性风险物质可能对人体健康构成潜在威胁,因此对化妆品进行严格的成分分析至关重要。传统的分析方法主要以已知风险物质为依据进行靶向分析,难以有效检测未知风险物质。相比之下,基于高分辨质谱的非靶向筛查技术具有高灵敏度、高分辨率和高精度等特性,能够全面快速地检测化妆品中的未知风险物质。本文介绍了基于高分辨质谱的非靶向筛查方法在化妆品安全性风险物质监管中的技术优势、工作流程、应用案例以及未来发展趋势。可以预见,非靶向筛查方法的进一步发展和应用将显著提升化妆品的安全性和质量可靠性,为使用者的健康和安全提供更有力的保障。Safety risk substances present in cosmetics can pose potential threats to human health,making strict component analysis essential.Traditional analysis methods primarily rely on targeted analysis based on known risk substances,which makes it difficult to effectively detect unknown hazards.In contrast,non-targeted screening technology based on high-resolution mass spectrometry is characterized by high sensitivity,high resolution,and high precision,enabling comprehensive and rapid detection of unknown risk substances in cosmetics.This paper details the technical advantages,workflow,application cases,and future development trends of the non-targeted screening method in the supervision of cosmetic safety risk substances.It is anticipated that further development and application of non-targeted screening methods will significantly enhance the safety and quality reliability of cosmetics,thereby providing stronger health and safety protection for consumers.

关 键 词：非靶向筛查 高分辨质谱 化妆品 安全性风险物质 分子网络 

分 类 号：R95[医药卫生—药学]