可达龙注射液在急诊快速型心律失常患者中的短期疗效及不良反应分析  

Analysis of Short-Term Efficacy and Adverse Reactions of Amiodarone Injection in Emergency Patients with Rapid Arrhythmias

作　　者：沈慧芳 SHEN Huifang(Department of Emergency Medicine,the Fourth Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210031,China)

机构地区：[1]南京医科大学第四附属医院急诊医学科,江苏南京210031

出　　处：《生物医学工程学进展》2025年第1期75-78,共4页Progress in Biomedical Engineering

摘　　要：背景急诊快速型心律失常,尤其是心房颤动和室性心动过速,常常威胁患者生命,需及时干预。可达龙注射液作为一种抗心律失常药物,已在急诊治疗中得到广泛应用。目的该研究旨在评估可达龙注射液在急诊快速型心律失常患者中的短期疗效及不良反应,为临床治疗提供依据。方法该研究回顾性分析了2019年1月至2022年12月在南京医科大学第四附属医院急诊科收治的80例快速型心律失常患者的临床数据。所有患者在急诊阶段均接受可达龙注射液治疗,并监测其疗效和不良反应。该研究主要评估患者心电图变化、脑钠肽(BNP)水平、心肌损伤标志物(如肌钙蛋白和肌酸激酶)变化。结果在80例患者中,72例(90%)心律恢复正常,心电图显示心房颤动或室性心动过速得到有效控制。治疗后,脑钠肽水平显著下降,心肌损伤标志物(如肌钙蛋白和肌酸激酶)有显著改善。不良反应发生率为7.5%,主要表现为轻微低血压和胃肠不适。结论可达龙注射液在急诊快速型心律失常患者中的短期疗效显著,能够有效恢复心律,改善心肌缺血,降低脑钠肽水平;不良反应较少,适合在急诊中作为一线治疗药物使用,但应根据患者的个体差异调整治疗方案,避免潜在不良反应。Background Rapid arrhythmias in emergency settings,particularly atrial fibrillation and ventricular tachycardia,often pose a threat to patients’lives and require timely intervention.Amiodarone injection,as an anti-arrhythmic medication,has been widely used in emergency treatment.Objective This study aims to evaluate the short-term efficacy and adverse reactions of amiodarone injection in emergency patients with rapid arrhythmias,providing evidence for clinical treatment.Methods This retrospective study analyzed the clinical data of 80 patients with rapid arrhythmias admitted to the emergency department of the Fourth Affiliated Hospital of Nanjing Medical University from January 2019 to December 2022.All patients received amiodarone injection during the emergency phase,and its efficacy and adverse reactions were monitored.The study primarily assessed changes in patients’electrocardiograms(ECGs),brain natriuretic peptide(BNP)levels,myocardial injury markers(e.g.,troponin,creatine kinase),and the combined effect of digoxin injection.Results Among the 80 patients,72(90%)achieved normal heart rhythm,with ECGs demonstrating effective control of atrial fibrillation or ventricular tachycardia.After treatment,BNP levels significantly decreased,and myocardial injury markers(e.g.,troponin and creatine kinase)showed marked improvement.The incidence of adverse reactions was 7.5%,mainly presenting as mild hypotension and gastrointestinal discomfort.Conclusion Amiodarone injection demonstrates significant short-term efficacy in emergency patients with rapid arrhythmias,effectively restoring heart rhythm,improving myocardial ischemia,and reducing BNP levels.With a low incidence of adverse reactions,it is suitable as a first-line treatment in emergency settings.However,treatment plans should be tailored to individual patients to avoid potential adverse effects.

关 键 词：可达龙注射液 急诊 快速型心律失常 短期疗效 不良反应 

分 类 号：R541.7[医药卫生—心血管疾病]