不同运动强度对老老年单纯收缩期高血压患者同型半胱氨酸水平的影响  

The Effect of Different Exercise Intensities on Homocysteine in Elderly Patients with Isolated Systolic Hypertension

作　　者：余冰清 陈梦瑶 陆贺青 方聪 YU Bingqing;CHEN Mengyao;LU Heqing;FANG Cong(Department of Rehabilitation Medicine,Chun’an County First People’s Hospital,Hangzhou,Zhengjiang 311700,China)

机构地区：[1]淳安县第一人民医院康复医学科,浙江杭州311700

出　　处：《生物医学工程学进展》2025年第1期85-90,共6页Progress in Biomedical Engineering

基　　金：杭州市医药卫生科技项目(B20200149)。

摘　　要：目的探讨不同运动强度对老老年单纯收缩期高血压(ISH)患者同型半胱氨酸水平(Hcy)的影响。方法将85例老老年ISH患者随机分为低强度运动组(以下简称“低强度组”,n=28)、中强度运动组(以下简称“中强度组”,n=27)和自然活动组(以下简称“对照组”,n=30)。3组患者在血压控制达标的前提下按设定的运动强度运动,在运动后1小时、24小时、12周及24周后,以Hcy作为评价指标,观察不同运动强度对老老年ISH患者Hcy的影响。结果运动后1小时,低、中强度组Hcy均升高[(15.28±4.00)vs(15.49±3.94),P<0.05;(15.32±4.03)vs(15.61±3.76),P<0.05];运动后24小时,低、中强度组Hcy均恢复至基线水平[(15.28±4.00)vs(15.28±4.00),P>0.05;(15.32±4.03)vs(15.33±4.02),P>0.05];运动12周后,中强度组Hcy降低[(15.32±4.03)vs(13.45±2.85),P<0.05];运动24周后,低、中强度组Hcy均降低[(15.28±4.00)vs(13.61±2.58),P<0.05;(15.32±4.03)vs(13.00±2.56),P<0.05],两组间无统计学差异(P>0.05)。结论短期急性运动会增加老老年ISH患者Hcy水平,与运动强度无关,但急性运动后Hcy升高是短暂的,可在24小时内恢复至基线水平。12周的中强度运动能降低老老年ISH患者Hcy水平,24周的低、中强度运动均能降低老老年ISH患者Hcy水平。Objective To investigate the effect of different exercise intensities on homocysteine in elderly patients with isolated systolic hypertension(ISH).Methods Eighty-five elderly ISH patients were randomly divided into a low intensity exercise group(hereinafter referred to as“low intensity group”,n=28),a moderate intensity exercise group(hereinafter referred to as“moderate intensity group”,n=27)and a natural activity group(hereinafter referred to as“control group”,n=30).Under the premise of achieving blood pressure control,the three groups were exercised according to the set exercise intensity.Hcy were measured as an evaluation index atonehour,24 hours,12 weeks and 24 weeks after exercise to observe the influence of different exercise intensity on Hcy in elderly ISH patients.Result At one hour after exercise,Hcy increased both in low and moderate intensity groups[(15.28±4.00)vs(15.49±3.94),P<0.05.(15.32±4.03)vs(15.61±3.76),P<0.05].At 24 hours after exercise,Hcy in low and moderate intensity groups recovered to baseline level[((15.28±4.00)vs(15.28±4.00),P>0.05;(15.32±4.03)vs(15.33±4.02),P>0.05].After 12 weeks of exercise,Hcy in moderate intensity group decreased[(15.32±4.03)vs(13.45±2.85),P<0.05].After 24 weeks of exercise,Hcy in low and moderate intensity groups both decreased[(15.28±4.00)vs(13.61±2.58),P<0.05;(15.32±4.03)vs(13.00±2.56),P<0.05],there was no statistical difference between the two groups.Conclusion Short-term acute exercise will increased the level of Hcy in elderly ISH patients,regardless of exercise intensity.However,the increase of Hcy after acute exercise was short-lived and recovered to baseline level within 24 hours.Moderate intensity of exercise for 12 weeks will decrease Hcys levels of elderly ISH patients,and both low and moderate intensity of exercises for 24 weeks will decrease Hcy levels of elderly ISH patients.

关 键 词：运动强度 单纯收缩期高血压 同型半胱氨酸 

分 类 号：R493[医药卫生—康复医学]