从代谢紊乱探讨急性胰腺炎卫气营血传变病机内涵  

Exploring the Pathogenesis Connotation of Wei-Qi-Ying-Xue Transmission in Acute Pancreatitis from a Metabolic Perspective

作　　者：邱祺 韩晨霞 金涛[1] 夏庆[1] 杜丹[1,2] QIU Qi;HAN Chenxia;JIN Tao;XIA Qing;DU Dan(West China Centre of Excellence for Pancreatitis,Institute of Integrated Traditional Chinese and Western Medicine,West China Hospital,Sichuan University,Chengdu 610041,China;Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610213,China)

机构地区：[1]四川大学华西医院中西医结合中心,胰腺炎中心,四川成都610041 [2]四川大学疾病分子网络前沿科学中心,四川成都610213

出　　处：《南京中医药大学学报》2025年第3期300-305,共6页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82374256);四川省自然科学基金青年基金项目(2023NSFSC1755)。

摘　　要：急性胰腺炎(AP)病程遵循卫气营血传变规律,存在动态的演变,而贯穿疾病全程的代谢紊乱状态作为致病因素和病理产物可归属于中医学“浊毒”范畴。精微物质代谢异常是AP卫气营血传变的启变要素,能量代谢障碍是AP气分期浊邪郁热的病理基础,代谢环境变化进一步加剧机体炎症反应,致邪热炽盛、瘀毒内蕴,促进AP由气分入营血。提出“把住气分关”、重塑代谢稳态可能是早期截断AP病势传变的关键。以代谢为切入点,结合浊毒理论探讨AP卫气营血传变的病机内涵,既丰富了卫气营血辨证的科学内涵,也为中医药防治AP重症化提供新思路。There is a dynamic and progressive relationship in acute pancreatitis(AP),following the principle of Wei-Qi-Ying-Xue transmission in traditional Chinese medicine(TCM).The metabolic disorders prevalent in AP can be attributed to the“turbid toxin”category in TCM,which runs throughout the disease as causative factors and pathologic products.The abnormal metabolism of subtle substances is the initiating factor of Wei-Qi-Ying-Xue transmission.Disorders of energy metabolism lay the pathologic basis of turbid evil and stagnant heat in the Qi stage of AP.Changes in the metabolic environment further exacerbate the inflammatory response resulting in the exuberance of pathogenic heat and the accumulation of blood stasis and toxins,promoting AP from the Qi division into the Ying-Xue stage.Therefore,we propose that“holding the Qi-fen juncture”and restoring metabolic homeostasis may be the keys to early truncation of AP disease progression.This paper explores the pathogenesis connotation of Wei-Qi-Ying-Xue transmission in AP from a metabolic perspective combined with the turbid toxin theory,which not only enriches the scientific connotation of Wei-Qi-Ying-Xue syndrome differentiation but also provides new ideas for the prevention and treatment of severe AP with TCM.

关 键 词：急性胰腺炎 卫气营血 传变 代谢 浊毒理论 代谢重编程 代谢稳态 

分 类 号：R259[医药卫生—中西医结合]