高龄孕妇全孕周维生素D水平序贯性调查及其补充方案效果评价  

A Sequential Survey of Vitamin D Levels in Elderly Pregnant Women Throughout Pregnancy and Evaluation of the Effectiveness of Supplemental Programs

作　　者：范琳 张蔓 刘兴会 杜洪涛 FAN Lin;ZHANG Man;LIU Xinghui(Departmert of Obstetrics and Gynecology,West China Second Hospital,Key Laboratory of Birth and Related Maternal and Child Diseases,Sichuan University,Chengdu Sichuan 610041,China)

机构地区：[1]四川大学华西第二医院产科出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041 [2]青岛双鲸药业股份有限公司,山东青岛266000

出　　处：《实用妇产科杂志》2025年第2期164-168,共5页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨成都市高龄孕妇血清维生素D含量情况和现有常规补充方案的效果。方法:选择2017年9月至2020年6月四川大学华西第二院收取的高龄孕妇样本中选取符合纳排标准的孕妇作为研究对象,填写相关调查问卷,采取钙剂联合多元维生素片进行补充,使用液相色谱串联质谱法检测孕早期(<14孕周)、中期(14~28孕周)、晚期(>28孕周)血清维生素D水平进行序贯调查及效果评价。结果:359例高龄孕妇孕早期体内维生素D平均含量为23.47±10.12μg/L,仅有22.01%孕妇维生素D充足,缺乏维生素D的高龄孕产妇常规补充维生素D后,维生素D水平随孕周增加而升高。维生素D水平在孕早期增幅较大,在孕中期即可达到33.47±10.12μg/L并在此后维持正常状态(F=187.255,P<0.01)。结论:纳入研究中的高龄孕妇普遍存在维生素D缺乏或不足的情况,有必要对其进行维生素D的筛查,且维生素D严重缺乏者应在孕早期额外补充维生素D制剂。Objective:To investigate the serum vitamin D levels of elderly pregnant women in Chengdu and evaluate the effectiveness of the existing conventional supplementation programs.Methods:Pregnant women who met the inclusion and exclusion criteria were selected from the samples of elderly pregnant women collected from the Second Hospital of West China,Sichuan University from September 2017 to June 2020 as the research subjects.Relevant survey questionnaires were filled out.Calcium tablets were supplemented with multivitamins.Their serum vitamin D levels were detected by liquid chromatography tandem mass spectrometry in early pregnancy(<14 weeks of gestation),mid pregnancy(14-28 weeks of gestation),and late pregnancy(>28 weeks of gestation)for sequential investigation and effect evaluation.Results:The average serum vitamin D level of 359 elderly pregnant women in the early stage of pregnancy was 23.47±10.12 ug/L,with only 22.01%of the pregnant women having sufficient vitamin D.The vitamin D levels of vitamin D-deficient elderly pregnant women increased as the gestational weeks increased after the routine supplementation of vitamin D.Vitamin D levels increased significantly in early pregnancy,reaching 33.47±10.12 ug/L and remain normal thereafter(F=187.255,P<0.01).Conclusion:Elderly pregnant women included in this study generally have vitamin D deficiency or insufficiency,and it is necessary to screen for vitamin D.Those with severe vitamin D deficiency should be supplemented with vitamin D preparations in the early stage of pregnancy.

关 键 词：维生素D 高龄孕妇 效果评价 

分 类 号：R715.3[医药卫生—妇产科学]