急性盆腔炎性疾病患者中医证型与血清NLR、PCT、CRP、IL-6的相关性研究  

Study on the Correlation Between Traditional Chinese Medicine Syndrome Types and Serum NLR,PCT,CRP and IL-6 in Patients with Acute Pelvic Inflammatory Diseases

作　　者：陈冬兰 朱晓鸥 CHEN Donglan;ZHU Xiao'ou(Linhai Hospital of Traditional Chinese Medicine,Linhai 317000 Zhejiang,China)

机构地区：[1]临海市中医院,浙江临海317000

出　　处：《广州中医药大学学报》2025年第4期827-832,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：浙江省自然科学基金项目(编号:2023J011898)。

摘　　要：【目的】评估急性盆腔炎性疾病(APID)患者中医证型与中性粒细胞与淋巴细胞计数比值(NLR)、降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素6(IL-6)水平的相关性,从而评估NLR、PCT、CRP、IL-6在APID患者中的诊断意义。【方法】选取符合纳入标准的110例于2020年1月~2024年3月在临海市中医院妇科门诊及住院部接受治疗的APID患者,根据中医辨证分型标准分为热毒炽盛证60例和湿热瘀阻50例,比较不同中医证型的NLR、PCT、CRP、IL-6、炎性包块直径、盆腔积液深度水平,分析NLR、PCT、CRP、IL-6与炎性包块直径、盆腔积液深度的关系,探讨APID患者预后与NLR、PCT、CRP、IL-6、炎性包块直径、盆腔积液深度的关系,以及不同中医证型APID患者与NLR、PCT、CRP、IL-6、炎性包块直径、盆腔积液深度的相关性。【结果】热毒炽盛证患者的NLR、PCT、CRP、IL-6水平及炎性包块直径、盆腔积液深度均明显高于湿热瘀阻证(P<0.05或P<0.01)。Spearman相关分析结果显示,NLR、PCT、CRP、IL-6水平与炎性包块直径、盆腔积液深度呈正相关(P<0.01)。Logistic回归分析结果显示,NLR、PCT、CRP、IL-6水平及炎性包块直径、盆腔积液深度与APID预后呈负相关(P<0.05或P<0.01)。多因素Logistic回归分析结果显示,NLR、PCT、CRP、IL-6水平及炎性包块直径、盆腔积液深度与热毒炽盛证、湿热瘀阻证均呈正相关(P<0.05或P<0.01)。【结论】热毒炽盛证患者NLR、PCT、CRP、IL-6水平高于湿热瘀阻证,NLR、PCT、CRP、IL-6有可能成为APID中医辨证的潜在生物学指标。Objective To investigate the correlation between traditional Chinese medicine(TCM)syndrome types and serum level of neutrophil-to-lymphocyte ratio(NLR),procalcitonin(PCT),C-reactive protein(CRP),and interleukin 6(IL-6)in the patients with acute pelvic inflammatory disease(APID),and to assess the diagnostic value of NLR,PCT,CRP,and IL-6 for APID patients.Methods A total of 110 patients with APID who met the inclusion criteria and were admitted to the Gynecology Outpatient and Inpatient Departments of Linhai Hospital of Traditional Chinese Medicine from January 2020 to March 2024 were selected,and were classified into 60 cases of excessive heat-toxin syndrome and 50 cases of dampness-heat-stasis obstruction syndrome according to the criteria of TCM syndrome differentiation.The levels of serum indicators of NLR,PCT,CRP and IL-6,diameter of inflammatory masses,and depth of pelvic effusion were compared between the two TCM syndrome types,and the correlation of serum indicator levels with inflammatory mass diameter and depth of pelvic effusion was analyzed.Moreover,the correlation of serum indicator levels,diameter of inflammatory masses,and depth of pelvic effusion with the prognosis of APID and their correlation with TCM syndrome types were investigated.Results Levels of serum indicators of NLR,PCT,CRP,and IL-6,inflammatory mass diameter and depth of pelvic effusion in the patients of excessive heat-toxin syndrome were significantly higher than those in the patients of dampness-heat-stasis obstruction syndrome(P<0.05 or P<0.01).Results of Spearman correlation analysis showed that the levels of serum indicators of NLR,PCT,CRP,and IL-6 were positively correlated with the diameter of inflammatory masses and depth of pelvic effusion(P<0.01).Results of Logistic regression analysis showed that the serum indicator levels,diameter of inflammatory masses,and depth of pelvic effusion were negatively correlated with APID prognosis(P<0.05 or P<0.01).Results of multivariate logistic regression showed thattheserum indicatorlevels,

关 键 词：急性盆腔炎性疾病 中医证型 热毒炽盛证 湿热瘀阻证 中性粒细胞与淋巴细胞计数比值 降钙素原 C反应蛋白 白细胞介素6 

分 类 号：R271.9[医药卫生—中西医结合]