补肾通脉方治疗肾虚血瘀型2型糖尿病合并动脉粥样硬化性心血管疾病的临床疗效及对血清miR-126的影响  

Clinical Efficacy of Bushen Tongmai Prescription in Treating Type 2 Diabetes Mellitus Complicated with Atherosclerotic Cardiovascular Disease of Kidney Deficiency and Blood Stasis Type and Its Influence on Serum Mir-126

作　　者：胡毅澜 宋晓丹 温妙瑜 罗陆一[2] 程红[1,2] HU Yilan;SONG Xiaodan;WEN Miaoyu;LUO Luyi;CHENG Hong(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《广州中医药大学学报》2025年第4期842-848,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20221354);深圳市科技计划项目(编号:JCYJ20180305163238685);深圳市中医院“3030”计划项目(编号:G3030202134)。

摘　　要：【目的】探讨补肾通脉方治疗2型糖尿病(T2DM)合并动脉粥样硬化性心血管疾病(ASCVD)肾虚血瘀型患者的临床疗效及对血清微小RNA-126(miR-126)的影响。【方法】将2023年3月至2023年10月在深圳市中医院老年医学科门诊及住院部就诊的60例T2DM合并ASCVD肾虚血瘀型患者按随机数字表法随机分为研究组和对照组,每组各30例。2组患者均实施低盐低脂糖尿病饮食和运动干预,并给予降糖、调脂、降血压、抗血小板聚集等常规西药治疗,研究组在对照组的基础上给予补肾通脉方治疗,疗程为8周。观察2组患者治疗前后C反应蛋白(CRP)、白细胞介素1β(IL-1β)、白细胞介素6(IL-6)、血管细胞黏附分子1(VCAM1)、miR-126、颈动脉内膜中层厚度(CIMT)、颈动脉斑块Crouse积分以及血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]的变化情况,并评估2组患者的颈动脉疗效和用药安全性。【结果】(1)血清miR-126水平方面:治疗后,研究组患者的血清miR-126水平较治疗前明显升高(P<0.01),对照组的血清miR-126水平较治疗前有升高趋势,但差异无统计学意义(P>0.05);组间比较,研究组对血清miR-126水平的升高幅度明显优于对照组(P<0.05)。(2)血清VCAM1水平方面:治疗后,研究组患者的血清VCAM1水平较治疗前明显下降(P<0.01),对照组患者的血清VCAM1水平较治疗前有下降趋势,但差异无统计学意义(P>0.05);组间比较,研究组对血清VCAM1水平的下降幅度明显优于对照组(P<0.01)。(3)血清炎症因子方面:治疗后,2组患者的血清CRP、IL-1β、IL-6水平均较治疗前下降(P<0.05或P<0.01),且研究组对血清IL-1β、IL-6水平的下降幅度均明显优于对照组(P<0.05)。(4)血脂指标方面:治疗后,研究组患者的TC、TG、LDL-C水平较治疗前下降(P<0.01),HDL-C水平较治疗前升高(P<0.01),而对照组患者的TC、TG、LDL-C、HDL-C水平均无明显�Objective To observe the clinical efficacy ofBushen Tongmai Prescription in treating type 2 diabetes mellitus(T2DM)complicated with atherosclerotic cardiovascular disease(ASCVD)of kidney deficiency and blood stasis type,and to investigate its effect on serum microRNA-126(miR-126).Methods Sixty patients with T2DM complicated with ASCVD of kidney deficiency and blood stasis type who admitted to the outpatient and inpatient departments of the Department of Geriatric Medicine of Shenzhen Traditional Chinese Medicine Hospital from March 2023 to October 2023 were randomly divided into the study group and the control group according to random number table method,with 30 patients in each group.All patients in the two groups were required to take low-salt and low-fat diabetic diet and exercise for intervention,and were also given the conventional western medical treatment with hypoglycemic,lipid-lowering,antihypertensive,anti-platelet aggregation agents.Additionally,the study group was treated withBushen Tongmai Prescription.The course of treatment for the two groups covered eight weeks.Before and after treatments,the two groups were observed in the changes of C-reactive protein(CRP),interleukin 1β(IL-1β),interleukin 6(IL-6),vascular cell adhesion molecule 1(VCAM1),miR-126,carotid intima-media thickness(CIMT),carotid plaque Crouse scores,and blood lipid indicators of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).After treatment,the therapeutic efficacy on carotid artery and drug safety in the two groups were evaluated.Results(1)After treatment,the serum miR-126 level in the study group was significantly increased compared with that before treatment(P<0.01),but the level in the control group only showed a rising trend and the difference was not statistically significant(P>0.05).The comparison between the two groups showed that the increase of serum miR-126 level in the study group was significantly superior to that in the control group(P<

关 键 词：2型糖尿病 动脉粥样硬化性心血管疾病 肾虚血瘀 补肾通脉方 MIR-126 血管细胞黏附分子1 炎症因子 

分 类 号：R259.872[医药卫生—中西医结合]