温阳益髓方联合富血小板血浆治疗早期膝骨关节炎  

Treatment of Early Knee Osteoarthritis with Platelet-Rich Plasma Combined with Wenyang Yisui Recipe

作　　者：王晓庆 荆琳[1] 闫奇[1] 何名江[1] 张洪美[1] 汤吉祥 刘思冶 WANG Xiaoqing;JING Lin;YAN Qi;HE Mingjiang;ZHANG Hongmei;TANG Jixiang;LIU Siye(Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China)

机构地区：[1]中国中医科学院望京医院,北京100102

出　　处：《中国中医骨伤科杂志》2025年第2期19-23,共5页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：中国中医科学院科技创新工程项目(C1201A02005);中央本级重大增减支项目(2060302)。

摘　　要：目的:观察富血小板血浆(PRP)联合温阳益髓方治疗早期膝骨关节炎的临床疗效。方法:选取2022年11月至2023年11月就诊的100例膝骨关节炎患者为研究对象,采用随机数字表法分为观察组和对照组各50例。观察组予膝关节腔注射富血小板血浆联合口服温阳益髓方辨证治疗,对照组采用单独富血小板血浆膝关节腔内注射治疗。疗程均为6周,于治疗前及治疗4周后和6周后比较两组患者膝关节疼痛视觉模拟量表(VAS)评分、西安大略和麦克马斯特大学(WOMAC)骨关节炎指数评分,检测白细胞介素1β(IL-1β)、关节液基质金属蛋白酶-13(MMP-13)水平变化,统计治疗期间两组患者不良反应发生情况。结果:观察组治疗后总有效率为86%,对照组总有效率为76%。治疗前,两组患者WOMAC评分及VAS评分差异无统计学意义(P>0.05),治疗4周后及6周后,观察组患者WOMAC评分及VAS评分优于对照组,差异有统计学意义(P<0.05),观察组较对照组的IL-1β、MMP-13水平显著降低,差异有统计学意义(P<0.05)。结论:温阳益髓方联合富血小板血浆治疗早期膝骨关节炎,可明显改善膝关节疼痛症状,恢复关节功能。Objective:To observe the clinical efficacy of platelet-rich plasma(PRP)combined with self-designed Wenyang Yisui recipea in the treatment of early knee osteoarthritis.Methods:A total of 100 patients with knee osteoarthritis admitted from November 2022 to November 2023 were selected as the study objects,and were divided into the observation group(50 cases)and the control group(50 cases)by random number table method.The observation group was treated with PRP injection into knee cavity combined with Wenyang Yisui recipe for syndrome differentiation.The control group was treated with single PRP intraluminal injection of knee joint.The treatment course of both groups was 6 weeks.Knee pain visual analogue scale(VAS)scores and Western Ontario and McMaster University(WOMAC)osteoarthritis index scores were compared before treatment and 4 and 6 weeks after treatment,respectively.The changes of interleukin-1β(IL-1β)and joint fluid matrix metalloproteinase-13(MMP-13)levels were detected,and the occurrence of adverse reactions in the two groups during treatment was analyzed.Results:The total effective rate was 86%in the observation group and 76%in the control group.Before treatment,there was no statistical significance in WOMAC score and VAS score between the two groups(P>0.05).After 4 and 6 weeks of treatment,WOMAC score and VAS score in the observation group were better than those in the control group(P<0.05),and IL-1βand MMP-13 levels in the observation group were significantly lower than those in the control group,with statistical significance(P<0.05).Conclusion:Wenyang Yisui recipe combined with platelet-rich plasma in the treatment of early knee osteoarthritis can effectively improve the symptoms of knee pain and restore joint function.

关 键 词：膝骨关节炎 富血小板血浆 温阳益髓方 促炎因子 

分 类 号：R684.3[医药卫生—骨科学]