肠道菌群改变引起外周血免疫细胞失衡与老年性阴道炎复发的相关性  

Relationship between immune cell imbalance in peripheral blood caused by changes in intestinal flora and elderly vaginitis recurrence

作　　者：陈佳[1,2] 钱晓燕[2] 倪惠华 徐旭娟[1,2] CHEN Jia;QIAN Xiaoyan;NI Huihua;XU Xujuan(School of Nursing and Rehabilitation,Nantong University,Jiangsu,Nantong 226001,China;不详)

机构地区：[1]南通大学护理与康复学院,江苏南通226001 [2]南通大学附属医院妇科

出　　处：《中国微生态学杂志》2025年第1期94-100,共7页Chinese Journal of Microecology

基　　金：南通市卫生健康委员会科研课题(QNZ2023020)。

摘　　要：目的研究肠道菌群变化对外周血免疫细胞失衡的影响,并分析其与老年性阴道炎复发之间的关系。方法选取2022年5月至2024年2月于我院就诊的120名老年患者,分为健康对照组(n=40)、单次阴道炎组(n=40)和阴道炎复发组(n=40)。使用高通量测序技术分析各组对象肠道菌群的结构及数量变化,同时检测外周血免疫细胞亚群指标水平变化。结果与健康对照组相比,单次阴道炎组患者肠道菌群多样性和丰富度改变差异无统计学意义(均P>0.05),阴道炎复发组的肠道菌群多样性和丰富度显著降低(均P<0.001)。阴道炎复发组患者肠道肠球菌、大肠埃希菌和拟杆菌数量显著增加(均P<0.05),而双歧杆菌、乳杆菌数量显著减少(均P<0.05)。此外,阴道炎复发组和单次阴道炎组患者外周血中性粒细胞和单核细胞水平显著升高(均P<0.05),而T细胞和B细胞水平显著降低(均P<0.05)。结论肠道菌群的改变可以通过影响外周血免疫细胞的分布导致老年患者阴道炎的复发,且两者之间存在密切相关性。Objective To observe the influence of intestinal flora changes on immune cell imbalance in peripheral blood,and analyze the relationship between intestinal flora changes and elderly vaginitis recurrence.Methods A total of 120 elderly patients treated in our hospital from May 2022 to February 2024 were enrolled and divided into healthy control group(n=40),single vaginitis group(n=40)and recurrent vaginitis group(n=40).High-throughput sequencing was used to analyze the changes of intestinal flora structure and quantity in each group,and the changes of peripheral blood immune cell subsets were detected.Results Compared with the healthy control group,there were no significant changes in the diversity and richness of intestinal flora in the single vaginitis group(all P>0.05),while those in the recurrent vaginitis group significantly reduced(all P<0.001).The counts of Enterococcus,Escherichia coli and Bacteroides in recurrent vaginitis group significantly increased(all P<0.05),while those of Bifidobacterium and Lactobacillus decreased significantly(all P<0.05).The levels of peripheral blood neutrophils and mononuclear macrophages in the recurrent vaginitis group and the single vaginitis group significantly increased(all P<0.05),while those of T cell and B cell significantly reduced(all P<0.05).Conclusion Intestinal flora imbalance may promote the recurrence of vaginitis in elderly patients by affecting the distribution of peripheral blood immune cells,and there is a close correlation between the two.

关 键 词：外周血免疫细胞 老年性阴道炎 肠道菌群 

分 类 号：R392[医药卫生—免疫学]