Clinical observation of efficacy in adhesive intestinal obstruction with Integrated Chinese(Chaihu Shugan San,柴胡疏肝散)and Western Medicine:a randomized controlled trial  

作　　者：ZHANG Xin CAO Jia LUO Chengping FAN Yibin DU Jie 

机构地区：[1]Gansu University of Chinese Medicine,Lanzhou 730050,China [2]Department of Gastrointestinal Surgery,Gaoping District People's Hospital and The Affiliated Hospital of China West Normal University,Nanchong 637000,China [3]Department of Traditional Chinese Medicine and Surgery,Nanchong Traditional Chinese Medicine Hospital affiliated to North Sichuan Medical College and Nanchong Hospital of Traditional Chinese Medicine,Nanchong 637000,China [4]Department of Urology and Pelvic Surgery and Andrology,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Journal of Traditional Chinese Medicine》2025年第1期115-122,共8页中医杂志(英文版)

基　　金：Nanchong City Science and Technology Plan Project:the Application of Tongli Shugan Liqi Method in the Treatment of Adhesive Intestinal Obstruction and its Effect on Inflammatory Indicators Interleukin-6,C-reactive protein and Procalcitonin(21YFZJ0108)。

摘　　要：OBJECTIVE:To explore the treatment efficacy of integrated Chinese medicine(Chaihu Shugan San,柴胡疏肝散,CSS)and western therapy in the treatment of adhesive intestinal obstruction(AIO),to provide new ideas for the management of the disease.METHODS:In our single-blind randomized controlled study,120 patients with AIO who were hospitalized in The Affiliated Hospital of China West Normal University Nan Chong Gaoping District People's Hospital from January 2021 to June 2022 and met the inclusion criteria were categorized into the treatment group and the control group.Patients from the control group were administered basic Western Medicine therapy,whereas patients from the treatment group were administered basic Western Medicine therapy plus CSS by gastric tube injection.Subsequently,the time to first anal exhaustion and defecation,time to relief of abdominal distension and pain,days of hospitalization,Traditional Chinese Medicine(TCM)symptom scores,interleukin-6(IL-6),C-reactive protein(CRP)and procalcitonin(PCT)levels in the 2 groups were recorded and compared.RESULTS:The comparison of clinical efficacy of the treatment group were better than the control group.The TCM symptom score was considerably lower in the treatment group;the inflammation indicators CRP,IL-6,and PCT also decreased statistically when comparing the control group.Furthermore,there were significantly reduced in the time to first exhaustion,time to first defecation,time to relief of abdominal pain and distension,and days of hospitalization in the treatment group versus the control group.CONCLUSION:CSS could suppress the inflammatory reaction,reduce days of hospitalization,relieve clinical symptoms in AIO patients with reliable efficacy and high safety and is worthy of clinical application.

关 键 词：intestinal obstruction INTERLEUKINS C-reactive protein post-abdominal surgery 

分 类 号：R73[医药卫生—肿瘤]