基于R语言的袁金声治疗冠心病稳定型心绞痛用药规律分析  

Analysis on the medication rule of Yuan Jinsheng in the treatment of stable angina pectoris of coronary heart disease based on R language

作　　者：杨进 王文佳 舒华 李正胜 王倩 胡蓉[3] 谢敏 袁金声 Yang Jin;Wang Wenjia;Shu Hua;Li Zhengsheng;Wang Qian;Hu Rong;Xie Min;Yuan Jinsheng(Department of Cardiology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;Department of Nephropathy,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,China;Department of General Practice,Guizhou Provincial People's Hospital,Guiyang 550001,China)

机构地区：[1]贵州中医药大学第二附属医院心血管内科,贵阳550003 [2]贵州中医药大学第二附属医院肾内科,贵阳550003 [3]贵州省人民医院全科医学科,贵阳550001

出　　处：《国际中医中药杂志》2025年第3期394-400,共7页International Journal of Traditional Chinese Medicine

基　　金：全国名中医袁金声工作室建设项目(国中医药办人教函〔2022〕245号、黔中医药函〔2023〕2号)。

摘　　要：目的通过R语言数据挖掘技术总结袁金声教授治疗冠心病稳定型心绞痛的用药规律及学术经验。方法选取2016年1月1日-2023年9月30日袁教授治疗冠心病稳定型心绞痛患者的有效门诊医案,运用R 4.2.3对处方药物进行频次统计、关联规则分析、系统聚类分析及相关性分析。结果共纳入处方292首,涉及患者268例,中药204种,中药总频次4253次。用药药性以温、平为主,药味以苦、辛、甘为主,归经以脾、肺、肝经为主。关联规则分析得出核心中药组合125组,常用药对为瓜蒌皮-枳实,并得到由枳实、川芎、瓜蒌皮、陈皮、丹参组成的核心方。系统聚类分析得到7类中药群组。相关性分析得到phi系数大于0.6的药对8组。结论研究认为,冠心病稳定型心绞痛病位在心,与肺、脾、肝、肾相关,本虚标实、痰瘀气滞是其重要病理因素,治疗以益气通阳宣痹、化痰活血行气为基本治法,体现袁教授“以通为要,燮理五脏,权衡标本”的学术思想与辨治原则。Objective To summarize the medication law and academic experience of Professor Yuan Jinsheng in the treatment of angina pectoris(AP)of coronary heart disease(CHD)through R language data mining technique.Methods The effective outpatient medical records of Professor Yuan Jinsheng in the treatment of AP of CHD from January 1,2016 to September 30,2023 were selected,and the R 4.2.3 was used for frequency statistics,association rule analysis,systematic clustering analysis and correlation analysis of prescription drugs.Results A total of 292 prescriptions were included,including 268 patients,involving 204 kinds of Chinese materia medica,and the total frequency of Chinese materia medica was 4253 times.The main properties were warm and neutral,the main tastes were bitter,pungent and sweet,and the main meridians were spleen,lung and liver meridians.The analysis of association rules obtained 125 core TCM combinations,and the commonly used drug pair was Trichosanthis Fructus-Aurantii Fructus Immaturus.The core prescription composed of Aurantii Fructus Immaturus,Chuanxiong Rhizoma,Trichosanthis Fructus,Citri Reticulatae Pericarpium and Salviea Miltiorrhizae Radix et Rhizoma.Seven TCM groups of were obtained by systematic clustering analysis.Correlation analysis showed that the drug pairs with phi coefficient greater than 0.6 were in 8 groups.Conclusions Studies suggest that AP of CHD is located in the heart,which is related to lung,spleen,liver and kidney,deficiency in root and excess in superficiality,phlegm,blood stasis and qi stagnation are important pathological factors.The treatment is based on the basic principles of tonifying qi,promoting yang,relieving rheumatism,resolving phlegm,activating blood circulation,and promoting qi circulation.It embodies Professor Yuan's academic thoughts and principles of differentiation and treatments of"taking fluency as the main point,regulating the five internal organs and weighing the root and superficiality".

关 键 词：心绞痛 稳定型 R语言 数据挖掘 袁金声 名医经验 用药规律 学术传承 

分 类 号：R28[医药卫生—中药学]