雌激素活性中药的数据挖掘研究  

Study on data mining of Chinese materia medica with estrogen-activity

作　　者：高渝 王文艺 邢昊晴 全晓敏 唐美慧 安超[2] Gao Yu;Wang Wenyi;Xing Haoqing;Quan Xiaomin;Tang Meihui;An Chao(Master Degree Student of Grade 2022,the Second Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100078,China;Master Degree Student of Grade 2023,the Second Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100078,China;Master Degree Student of Grade 2021,the Second Clinical Medical College of Beijing University of Chinese Medicine,Beijing 100078,China;Department of Oncology,Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第二临床医学院,北京100078 [2]北京中医药大学东方医院肿瘤科,北京100078

出　　处：《国际中医中药杂志》2025年第3期401-406,共6页International Journal of Traditional Chinese Medicine

基　　金：高等学校学科创新引智计划资助(B21028)。

摘　　要：目的基于数据挖掘总结雌激素活性中药并分析其特点。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、PubMed及Web of Science建库至2024年6月30日相关文献,筛选具有雌激素活性的中药。采用Excel 2021、KH Coder 3.0软件对中药功效分类、性味归经、雌激素活性筛选方法和应用情况等信息进行统计及网络共现分析。结果共纳入121味具有雌激素活性的中药,功效类别以补虚药、清热药及活血化瘀药居多,药性多为温、平,药味多为甘、苦,归经以肝、肾、脾经为主。功效分类与性味归经的网络共现分析以“补虚药-平-甘-肝-肾”的聚类关系最为显著。筛选方法主要包括MCF-7细胞增殖和子宫增重实验等。应用主要涵盖骨质疏松症、围绝经期综合征、脂代谢异常、卵巢早衰等方面。结论雌激素活性中药或其成分作用于雌激素靶细胞或器官,发挥类雌激素或拮抗雌激素作用。此类中药通过调节机体气血阴阳、脏腑功能、天癸的充盈和冲任二脉,改善人体生长发育、生殖和衰老。建议今后以中医理论指导临床用药为基础,结合现代医学研究技术和循证医学研究,进一步探究其有效成分、作用机制、双向作用及安全性。Objective To summarize Chinese materia medica with estrogen-activity based on data mining and analyze their characteristics.Methods Literature was retrieved from CNKI,Wanfang Data,Chongqing VIP,CBM,PubMed and Web of Science from the establishment of the databases to June 30,2024,and Chinese materia medica with estrogenic activity were screened.Excel 2021 and KH Coder 3.0 software were used to perform statistical and network co-occurrence analysis on the efficacy classification of Chinese materia medica,properties,tastes and meridians,screening methods for estrogen activity,and applications.Results Totally 121 kinds of Chinese materia medica with estrogen-activity were included in total.The efficacy classifications were mostly tonic medicines,heat-clearing medicines and blood circulation promoting drugs.The properties were mainly warm and neutral,the tastes were mainly sweet and bitter,and the meridians were mainly the liver,kidney and spleen meridians.The network co-occurrence analysis of the efficacy classification,properties,tastes and tropism meridians showed that the clustering relationship of tonic medicine-neutral-sweet-liver-kidney was the most obvious.The screening methods mainly included MCF-7 cell proliferation and uterine weight gain experiments.Their applications mainly covered osteoporosis,perimenopausal syndrome,lipid metabolism disorder,and premature ovarian failure,etc.Conclusions Chinese materia medica with estrogen-activity or their components act on estrogen target cells or organs to exert estrogen-like or antagonistic estrogenic effects.This kind of Chinese materia medica can regulate the body's qi,blood,yin and yang,the function of organs and the fullness of Tiangui,as well as the Chong meridian and Conception Vessel,thus improving human growth and development,reproduction and aging.In the future,it is suggested to explore their effective components,mechanisms,bidirectional effect and safety on the basis of guiding clinical medication with the theory of TCM,combining with modern medical resea

关 键 词：雌激素类(中药) 数据挖掘 功效分类 性味归经 筛选方法 应用 

分 类 号：R28[医药卫生—中药学]