基于药性传递理论和胃肠疾病药理作用的痛泻要方质量标志物预测分析  

Prediction and analysis of quality markers of Tongxieyao Prescription based on drug delivery theory and pharmacological effects of gastrointestinal diseases

作　　者：李季文[1] 毕映燕[1] 李俊江[1] 徐志伟[1] Li Jiwen;Bi Yingyan;Li Junjiang;Xu Zhiwei(Research Preparation Center,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院科研制剂中心,兰州730050

出　　处：《国际中医中药杂志》2025年第3期417-422,共6页International Journal of Traditional Chinese Medicine

基　　金：甘肃省科技厅重点研发计划项目(20YF8FA090)。

摘　　要：痛泻要方是治疗肝脾不和痛泄的经典方剂,在炎性肠病、功能性腹泻、慢性结肠炎等胃肠疾病治疗方面应用较广。基于药性传递理论探讨痛泻要方中药属性、化学成分及其治疗胃肠疾病药理作用的相关性,初步可推断痛泻要方整体药性偏温,味苦、甘、辛、酸,归肝、脾经,升降浮沉属性有“升”的趋势,具有胃肠道黏膜保护、肠道菌群调节、胃肠道动力改善等作用。结合中药质量标志物(Q-marker)“五原则”概念对痛泻要方潜在Q-marker进行预测分析,认为白术内酯Ⅰ、白术内酯Ⅱ、白术内酯Ⅲ、芍药苷、辛弗林、橙皮苷、橘皮素、川陈皮素、升麻素苷、5-O-甲基维斯阿米醇苷等可作为本方的Q-marker及其质控指标。Tongxieyao Prescription is a classic prescription for the treatment of liver-spleen disharmony,which is widely used in the treatment of gastrointestinal diseases such as inflammatory bowel disease,functional diarrhea and chronic colitis.This article explored the correlation between the properties,chemical components,and pharmacological effects of Chinese materia medica in the treatment of gastrointestinal diseases based on the theory of drug delivery in Tongxieyao Prescription.It can be preliminarily inferred that the overall medicinal properties of Tongxieyao Prescription are warm,bitter,sweet,pungent and sour,and belong to the liver and spleen meridians.The ascending,descending,floating and sinking properties have a"rising"trend,which has the effects of gastrointestinal mucosal protection,intestinal flora regulation,gastrointestinal motility improvement and so on.Combined with the concept of"five principles"of TCM quality marker(Q-marker),the potential Q-marker of Tongxieyao Prescription was predicted and analyzed.It was considered that atractylenolideⅠ,atractylenolideⅡ,atractylenolideⅢ,paeoniflorin,synephrine,hesperidin,tangeretin,nobiletin,prim-O-glucosylcimifugin,5-O-methylvisammioside,etc.could be used as Q-markers and quality control indicators of this prescription.

关 键 词：痛泻要方 胃肠疾病 药性传递 质量标志物 综述 

分 类 号：R28[医药卫生—中药学]