从“病-证-症-期-分子表型”探讨慢性心力衰竭的诊治规律  

To explore the rule of diagnosis and treatment of chronic heart failure from"disease-syndrome-symptom-stage-molecular phenotype"

作　　者：廉坤 孟骊冲 邓颖 赵震宇 李琳 胡志希 Lian Kun;Meng Lichong;Deng Ying;Zhao Zhenyu;Li Lin;Hu Zhixi(College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Graduate School,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医学院,长沙410208 [2]湖南中医药大学研究生院,长沙410208

出　　处：《国际中医中药杂志》2025年第2期150-156,共7页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82274412);广东省重点领域研发项目(2020B1111100001);湖南省自然科学基金(2023JJ30453);湖南省中医药科研课题(B2023045);长沙市自然科学基金(kq2208185)。

摘　　要：研究慢性心力衰竭的诊断与防治具有重要意义。以西医病名为纲,以中医证候为目,结合症状、体征、分期和分子表型等,探索慢性心力衰竭的中西医结合诊疗规律。认为慢性心力衰竭包括气虚血瘀证、阳虚血瘀证、气阴两虚证、心肾阳虚证和阳虚水泛证等多种证型;可出现胸闷气短、神疲乏力、肢体水肿和脉结代等多种临床表现;涉及心肌纤维化、炎症反应与心肌细胞损伤等多种病理机制和分子表型。治疗时应注意根据“病-证-症-期-分子表型”的特点,分早、中、晚三期治疗。It is of great significance to study the diagnosis,prevention and treatment of chronic heart failure.This study took the name of Western medicine disease as the main line,took TCM syndromes as the aim,combined the symptoms,signs,stages and molecular phenotype,and explored the diagnosis and treatment law of the disease.It is believed that chronic heart failure includes the syndrome of qi deficiency and blood stasis,yang deficiency and blood stasis,qi-yin deficiency,heart-kidney yang deficiency and yang deficiency water syndrome.There were many clinical manifestations such as chest tightness,shortness of breath,fatigue,limb edema and pulse knot.It involved many pathological mechanisms and molecular phenotype such as myocardial fibrosis,inflammatory response and myocardial cell injury.Treatment should be divided into early,middle and late stages according to the characteristics of"disease-syndrome-symptom-stagemolecular phenotype".

关 键 词：心力衰竭 诊治规律 中医证候 分子表型 病证结合 

分 类 号：R259[医药卫生—中西医结合]