基于病证结合的克罗恩病湿证量化诊断标准的回顾性分析与前瞻性研究  

Retrospective analysis and prospective study on quantitative diagnostic criteria for Crohn's disease with dampness syndrome based on disease syndrome combination

作　　者：郑婕 莫嘉浩 吴明慧 黄智斌[3] 刘刚[1] 何家鸣[1] 陈延[1] Zheng Jie;Mo Jiahao;Wu Minghui;Huang Zhibin;Liu Gang;He Jiaming;Chen Yan(Department of Gastroenterology,Fangcun Hospital of Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510370,China;The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Invigorating the Earth Academic School Studio,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广东省中医院芳村医院脾胃病科,广州510370 [2]广州中医药大学第二临床医学院,广州510405 [3]广东省中医院补土流派工作室,广州510120

出　　处：《国际中医中药杂志》2025年第2期165-170,共6页International Journal of Traditional Chinese Medicine

基　　金：广东省科技创新战略专项(pdjh2021b0123);广东省中医院朝阳人才立项课题(ZY2022YL09)。

摘　　要：目的基于临床数据的病证结合模式,建立克罗恩病湿证量化诊断标准并进行双向验证。方法选择2021年10月-2022年1月广东省中医院脾胃病科、中山大学第六附属医院消化科及广东省中医院门诊256例克罗恩病患者作为观察对象,采用随机数字表法按8∶2比例随机分为运算组205例和验证组51例,运用频数优势法、χ^(2)检验和二元Logistic回归分析法筛选相关标准因素,运用条件概率法给相关条目赋分,最大似然法确定量化诊断阈值,建立基于病证结合的克罗恩病湿证量化诊断标准,并对其进行回顾性分析及前瞻性验证。结果在候选20项克罗恩病湿证量化诊断标准条目基础上,进行二元Logistic回归分析计算各条目间的OR值,共获得舌苔腻(7分)、身体困重(13分)、腰膝酸软(8分)、头重(9分)、口淡无味(6分)、肛门重坠(8分)、排便不爽(8分)、大便黏腻(7分)8项条目及赋分,量化诊断阈值为11。结论克罗恩病湿证量化诊断标准相关条目赋分合理,诊断价值较好,可为克罗恩病的进一步证候量化研究提供参考。Objective To establish a quantitative diagnostic standard for Crohn's disease with dampness syndrome based on clinical data using a disease syndrome combination model and conduct bidirectional validation.Methods 256 patients with Crohn's disease from the Department of Spleen and Stomach Diseases at Guangdong Provincial Hospital of Chinese Medicine,the Department of Gastroenterology at the Sixth Affiliated Hospital of Sun Yat-sen University,and the Outpatient Department of Guangdong Provincial Hospital of Chinese Medicine from October 2021 to January 2022 were selected as the observation objects.They were divided into an operation group of 205 patients and a verification group of 51 patients in an 8:2 ratio using a random number table method.The frequency advantage method,χ^(2) test,and binary logistic regression analysis were used to screen for relevant standard factors.The conditional probability method was used to assign scores to relevant items,and the maximum likelihood method was used to determine the quantitative diagnostic threshold.A quantitative diagnostic standard for Crohn's disease with dampness syndrome based on disease syndrome combination was established,and it was retrospectively analyzed and prospectively verified.Results On the basis of the 20 candidate quantitative diagnostic criteria items for Crohn's disease dampness syndrome,binary logistic regression analysis was performed to calculate the OR values between each item.The quantitative diagnostic criteria for Crohn's disease with dampness syndrome included tongue coating greasiness(7 points),body heaviness(13 points),waist and knee soreness(8 points),head weight(9 points),bland mouth(6 points),anal heaviness(8 points),uncomfortable bowel movements(8 points),and sticky stools(7 points),with a quantitative diagnostic threshold of 11.Conclusion The scoring of relevant items in the quantitative diagnostic criteria for Crohn's disease with dampness syndrome is reasonable and has good diagnostic value,which can provide reference for further quanti

关 键 词：CROHN病 湿证 回顾性研究 前瞻性研究 回归分析 量化诊断 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]