基于LDA主题模型和关联规则的中药治疗糖尿病肾病组方配伍规律研究  

Study on the TCM compatibility law in the treatment of diabetic nephropathy based on LDA topic model and association rules

作　　者：吴敏 郑陆峰 徐惠 刘萍 陈小蓉 文天才[1] Wu Min;Zheng Lufeng;Xu Hui;Liu Ping;Chen Xiaorong;Wen Tiancai(Data Center of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Insititute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医药数据中心,北京100700 [2]中国中医科学院中医药信息研究所,北京100700 [3]中国中医科学院中医临床基础医学研究所,北京100700 [4]中国中医科学院中医基础理论研究所,北京100700

出　　处：《国际中医中药杂志》2025年第2期250-255,共6页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82374624);北京市自然科学基金(7232306);中国中医科学院基本科研业务费自主选题项目(ZZ16-XRZ-107-SJ)。

摘　　要：目的挖掘中医药治疗DN的用药思路和配伍规律。方法检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)和中国生物医学文献数据库(CBM)2000年1月1日-2023年12月31日收录的中药治疗DN的相关文献,采用Excel 2016建立数据库,分别采用Python 3.10和古今医案云平台2.3.5进行潜在狄利克雷分配(LDA)主题建模和关联规则分析,挖掘文献中的中药组方思路与配伍规律。结果共纳入文献474篇,包含处方474首,涉及中药260味,其中频次≥30的中药共40味,主要有黄芪、丹参、山药、茯苓、山萸肉等。LDA主题模型挖掘出3个方剂群,包含六味地黄丸、桃红四物汤、二至丸和五苓散4首经典方剂。关联规则得到常用药物组合泽泻-茯苓、牡丹皮-山萸肉和牡丹皮-山药。结论中医治疗DN以滋阴补肾为主要治法,辅以活血化瘀和利水渗湿药,现代医家多以经典方剂如六味地黄丸、二至丸、桃红四物汤和五苓散作为基础,根据患者具体病情加减化裁。LDA主题模型可从大量现代中医文献中提取有价值的方剂信息,为中医临床用药规律研究提供新视角和思路。Objective To explore the medication thinking and compatibility rules of TCM for the treatment of diabetic nephropathy(DN).Methods Relevant journal literature of TCM for the treatment of DN was retrieved from CNKI,Wanfang Data,VIP,and CBM from January 1,2000 to December 31,2023,and a database was established through Excel 2016.Python 3.10 and the ancient and modern medical record cloud platform 2.3.5 were used to conduct Latent Dirichlet Allocation(LDA)topic modeling and association rule analysis to explore the thinking and compatibility rules of TCM prescriptions in the literature.Results A total of 474 articles were included in the study,including 474 prescriptions,involving 260 kinds of Chinese materia medica,of which 40 kinds of Chinese materia medica with a frequency of≥30,mainly Astragali Radix,Salviae Miltiorrhizae Radix et Rhizoma,Dioscoreae Rhizoma,Poria,and Corni Fructus,etc.The LDA topic model identified three groups of prescriptions,including four classic prescriptions:Liuwei Dihuang Pills,Taohong Siwu Decoction,Erzhi Pills,and Wuling Powder.The commonly used drug combinations extracted by association rules were:Rhizoma Alismatis-Poria,Cortex Moutan Radicis-Fructus Corni and Cortex Moutan Radicis-Rhizoma Dioscoreae.Conclusions The main therapeutic principle of TCM in treating DN is to nourish the yin and tonify the kidney,supplemented by drugs that promoting blood circulation for removing blood stasis as well as promoting urination and draining dampness.In clinical application,modern doctors tend to use classic prescriptions such as Liuwei Dihuang Pills,Erzhi Pills,Taohong Siwu Decoction,and Wuling Powder as the basis,and modify them according to the specific conditions of patients.The LDA topic model can extract valuable prescription information from a large number of modern TCM literature,providing new perspectives and ideas for the study of clinical medication rules in TCM.

关 键 词：糖尿病肾病 中医药 LDA主题模型 关联规则 古今医案云平台 

分 类 号：R28[医药卫生—中药学]