基于《中华医典》挖掘病理性裂纹舌的文献研究  

Mining in Pathological Fissured Tongue Based on Chinese Medical Classics:A Literature Review

作　　者：张翼飞 张泽涵 陈佳祺 李健峰 姜伟艳 关静 ZHANG Yifei;ZHANG Zehan;CHEN Jiaqi;LI Jianfeng;JIANG Weiyan;GUAN Jing(TCM School of Beijing University of Chinese Medicine,Beijing 102488,China;Beijing Hospital of TCM Affiliated to Capital Medical University,Beijing 100010,China;School of Acupuncture,Moxibustion and Tuina of Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中医学院,北京102488 [2]首都医科大学附属北京中医医院,北京100010 [3]北京中医药大学针灸推拿学院,北京102488

出　　处：《西部中医药》2025年第3期63-69,共7页Western Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划(2017YFC1703302)。

摘　　要：目的:基于文献挖掘探讨病理性裂纹舌的证治特点与用药规律,以期为其在临床诊疗与预防中的应用提供依据,为相关研究开拓新思路。方法:以《中华医典》(第5版)数据库为文献来源,运用Excel 2019进行文献整理与筛选,并对纳入研究的证素、症状与用药数据进行频次统计。应用R Version 4.1.1对证素、症状与用药数据进行关联规则分析,并对频数≥8的高频用药进行相关性聚类分析。结果:纳入的110条文献记载以明清时期医著为主,病理性裂纹舌相关的病性证素主要包括火热、阴虚等,病位证素主要包括心、肺、胃等;关联规则分析得到24种证素组合,如“血虚-气虚”。与病理性裂纹舌同现频数较高的脉象为数脉、弦脉等,舌象为舌红、舌光等,其他症状包括口干、发热、心烦等;关联规则分析得到24种临床症状组合,如:脉大-脉数。病理性裂纹舌相关用药中出现频次较高的为黄芩、炙甘草、麦冬等;关联规则分析获取潜在用药配伍23条,如:川芎-当归;相关性聚类分析将频数≥8的高频用药划分为6类。结论:病理性裂纹舌主要与火热、气滞、正虚等病理因素相关,病位多位于心、肺、胃,常在热盛津伤证、气郁化火证、阴虚火旺证、气血两虚证等证型中出现,常与温热病的临床表现同时出现。治疗原则以清热泻火为主,随证兼用解郁、滋阴、益气、养血等治法,常用的基础方有黄连解毒汤、清营汤、十全大补汤等。Objective:To discuss the medication rules and the characteristics of the diagnosis and treatment of pathological fissured tongue based on data mining,with a view to providing a certain reference for the application of clinical diagnosis and treatment,and prevention,and opening up new ideas for the related studies.Methods:The fifth version of Chinese Medical Classics database was taken as the source of literature,Excel 2019 was applied to sort out and filter the literature,frequency of the syndrome elements,symptoms and medication data included in the study was statistically analyzed.R Version 4.1.1 was utilized to perform the association rules of the syndrome elements,symptoms and medication data,and to conduct the relevant cluster analysis of high-frequency medication with the frequency≥8.Results:All 110 papers included were medical works in the Ming and Qing dynasties,the syndrome elements of the nature of the disease related to fissured tongue mainly contained fire-heat,Yin deficiency,and the syndrome elements of location of the disease covered heart,lung and stomach;the analysis of association rules has yielded 24 combinations of syndrome elements,such as"blood deficiency-Qi deficiency".The high-frequency pulses manifested with pathological fissured tongue were fast pulse and stringy pulse,and the tongue manifestations contained red tongue and smooth tongue,other symptoms covered dry mouth,fever,vexation;the analysis of association rules has gained 24 combinations of clinical symptoms,including large pulserapid pulse.Higher-frequency herbs appeared in the medication were Huangqin(Scutellariae radix),Zhigancao(Glycyrrhizae radix et rhizoma praeparata cum melle)and Maidong(Ophiopogonis radix);23 potential medicinal compatibility were gained from association rule analysis,such as Chuanxiong(Chuanxiong rhizoma)-Danggui(Angelicae sinensis radix);high-frequency herbs with the frequency≥8 were classified into six kinds by the related cluster analysis.Conclusion:Pathological fissured tongue is mainly related to p

关 键 词：裂纹舌 数据挖掘 证素 症状 用药规律 《中华医典》 

分 类 号：R285[医药卫生—中药学]