归肾活血汤对原因不明月经过少患者基质金属蛋白酶水平及血液流变学的影响  

Effects of Guishen Huoxue Tang on MMP-2 Levels and Blood Rheology in Patients with Hypomenorrhea of Unknown Aetiology

作　　者：张文艳[1] 黄光荣 袁媛[1] 陈莉[1] ZHANG Wenyan;HUANG Guangrong;YUAN Yuan;CHEN Li(Baoan District Hospital of TCM,Shenzhen 518100,China)

机构地区：[1]深圳市宝安区中医院,广东深圳518100

出　　处：《西部中医药》2025年第3期118-121,共4页Western Journal of Traditional Chinese Medicine

基　　金：深圳市科技计划项目(JCYJ20220530141403008)。

摘　　要：目的:探讨归肾活血汤对原因不明月经过少患者基质金属蛋白酶2(matrix metalloproteinases 2,MMP-2)、MMP-9水平及血液流变学的影响。方法:选取96例原因不明月经过少患者,按随机数字表法将其分为对照组和观察组,各48例。对照组采取常规西药治疗,观察组在此基础上服用归肾活血汤治疗。两组均连续治疗3个月经周期。比较两组临床疗效、血液流变学指标值、基质金属蛋白酶水平、中医证候积分、月经量积分。结果:观察组临床总有效率[93.75%(45/48)]高于对照组[75.00%(36/48)](P<0.05);治疗后两组患者MMP-2、MMP-9水平均明显高于治疗前(P<0.05),且观察组高于对照组(P<0.05);治疗后两组月经量积分、中医证候积分、红细胞聚集指数、高切全血黏度、纤维蛋白原(fibrinogen,Fib)水平均低于治疗前,且观察组低于对照组(P<0.05)。结论:归肾活血汤治疗原因不明月经过少患者具有较好的疗效,能够有效调节患者机体性激素水平,并有利于提升子宫内膜中血管的生成活性。Objective:To discuss the effects of Guishen Huoxue Tang on the levels of MMP-2 and MMP-9,blood rheology in patients with hypomenorrhea of unknown aetiology.Methods:All 96 patients were chosen and allocated to the control group and the observation group according to random number table method with 48 cases in each group.The control group was treated with conventional Western medicine,and the observation group took Guishen Huoxue Tang,both groups were treated for three menstrual cycles consecutively.To compare clinical effects the indexes of blood rheology the levels of matrix metalloproteinases,TCM syndrome integrals,and the integration of menstrual flow,between both groups.Results:Clinical total effective rate of the observation group was[93.75%(45/48)],higher than[75.00%(36/48)]of the control group(P<0.05);after the treatment,the levels of MMP-2 and MMP-9 in the two groups were obviously higher than these before the treatment(P<0.05),and the observation group was higher than the control group(P<0.05);after the treatment,the integration of menstrual flow,TCM syndrome integrals,erythrocyte aggregation index,high-shear whole blood viscosity and the levels of Fib were lower than these before the treatment,and the observation group was lower than the control group(P<0.05).Conclusion:The decoction could gain better clinical effects in the treatment of hypomenorrhea of unknown aetiology,it could effectively regulate the levels of sex hormone and facilitate the enhancement of angiogenic activity in the endometrium.

关 键 词：月经过少 归肾活血汤 基质金属蛋白酶 性激素 临床疗效 

分 类 号：R271.11[医药卫生—中医妇科学]