瑞马唑仑在老年胸腰椎骨折手术麻醉中的应用研究  

Application of Remazolam in Anesthesia for Elderly Thoracic and Lumbar Vertebral Fracture Surgery

作　　者：张文杰 Zhang Wenjie(Department of Anesthesiology,The Orthopedic Hospital of Zhengzhou,Zhengzhou,Henan,45000,China)

机构地区：[1]郑州市骨科医院麻醉科,河南郑州45000

出　　处：《黑龙江医学》2025年第5期549-552,共4页Heilongjiang Medical Journal

摘　　要：目的:观察瑞马唑仑在老年胸腰椎骨折手术麻醉中的应用效果。方法:选取2022年2月—2023年9月郑州市骨科医院收治的112例胸腰椎压缩性骨折患者作为研究对象。随机分为常规组和瑞马唑仑组,每组各56例。常规组予以常规全身麻醉辅助手术,瑞马唑仑组采用瑞马唑仑联合全身麻醉辅助手术,比较两组患者围手术期呼吸循环功能、血液循环功能、术后镇静、镇痛情况及麻醉安全性。结果:在不同麻醉方案下,瑞马唑仑组患者术中呼吸频率均值略低于常规组,呼吸阻力指数(RI)均值略高于常规组,差异均无统计学意义(t=1.369、1.520,P>0.05);瑞马唑仑组患者术中心率(HR)均值、平均动脉压(MAP)均值略低于常规组,差异均无统计学意义(t=0.406、0.760,P>0.05)。瑞马唑仑组患者术后1 h、3 h、5 h、7 h的Ramsay镇静评分(RSS)高于常规组,视觉模拟量表(VAS)评分低于常规组,差异均有统计学意义(t=5.742、7.690、10.620、31.929、10.135、7.045、7.375、9.914,P<0.05)。瑞马唑仑组患者麻醉相关副反应发生率略高于常规组,差异无统计学意义(t=0.121,P>0.05)。结论:瑞马唑仑辅助全麻可在不影响胸腰椎骨折手术患者围手术期呼吸、血液循环功能同时,增强术后镇静、镇痛效果;联合应用此药未明显增强麻醉副反应发生风险,安全性较高。Objective:To observe the application effect of Remazolam in anesthesia for elderly patients with thoracolumbar vertebral fractures surgery.Methods:112 patients with thoracolumbar vertebral compression fractures admitted to the hospital from February 2022 to September 2023 were randomly selected.And they were divided into two groups:the conventional group(56 cases)and the remimazolam group(56 cases).The conventional group received conventional general anesthesia assisted surgery,while the remimazolam group received remimazolam combined with general anesthesia assisted surgery.The perioperative respiratory and circulatory function,blood circulation function,postoperative sedation and analgesia,and anesthesia safety between two groups of patients were compared.Results:Under different anesthesia regimens,the mean intraoperative respiratory rate in the remazolam group was slightly lower than that in the conventional group,and the mean respiratory resistance index(RI)was slightly higher than that in the conventional group(t=1.369,1.520;P>0.05).The mean operating heart rate(HR)and mean arterial pressure(MAP)of the remazolam group were slightly lower than those of the control group(t=0.406,0.760;P>0.05).The Ramsay sedation score(RSS)in the Remazolam group 1 h,3 h,5 h and 7 h after surgery was higher than that in the control group,and the Visual Analog Pain Scale(VAS)score was lower than that in the control group,with statistically significant difference(t=5.742,7.690,10.620,31.929,10.135,7.045,7,375,9.914;P<0.05).The incidence of anesthesia related side effects in the Rimazolam group was slightly higher than that in the conventional group,and the difference was not statistically significant(t=0.121,P>0.05).Conclusion:Remazolam assisted general anesthesia can enhance postoperative sedation and analgesia without affecting perioperative respiratory and circulatory functions in patients undergoing thoracolumbar fracture surgery.The combined use of this drug dose not significantly increase the risk of anesthesia side effects,

关 键 词：胸腰椎骨折 全身麻醉 瑞马唑仑 循环功能 麻醉安全性 

分 类 号：R274.1[医药卫生—中医骨伤科学]