卡前列素氨丁三醇对预防瘢痕子宫产后出血风险的应用研究  

Application Study of Carboprost Tromethamine in Preventing the Risk of Postpartum Hemorrhage in Scar Uterus

作　　者：崔萌杰 蔡大军 Cui Mengjie;Cai Dajun(Obstetrics,Jiaozuo Maternal and Child Health Hospital,Jiaozuo,Henan,454000,China)

机构地区：[1]焦作市妇幼保健院产科,河南焦作454000

出　　处：《黑龙江医学》2025年第6期684-687,共4页Heilongjiang Medical Journal

摘　　要：目的:观察卡前列素氨丁三醇对瘢痕子宫产后出血的防治效果。方法:选取2022年1月—2023年5月焦作市妇幼保健院收治的106例瘢痕子宫患者作为研究对象,采用计算机随机分组法将其分为常规组和试验组,每组各53例。常规组采用常规治疗,试验组采用卡前列素氨丁三醇辅助治疗,比较两组患者产后3 h、6 h、9 h的出血情况、止血情况、子宫动脉血流动力学参数、妊娠结局及用药安全性。结果:试验组患者产后3 h、6 h、9 h的出血量均低于常规组,差异均有统计学意义(t=3.259、3.775、2.437,P<0.05);试验组患者止血时间低于常规组,止血成功率高于常规组,差异均有统计学意义(t=12.357;χ^(2)=8.008,P<0.05);治疗后,试验组患者子宫动脉收缩期峰值流速/舒张期流速(S/D)、搏动指数(PI)均高于常规组,阻力指数(RI)低于常规组,差异均有统计学意义(t=4.242、6.410、4.198,P<0.05);试验组患者不良妊娠结局发生率为7.55%,低于常规组患者的22.64%,差异有统计学意义(χ^(2)=8.884,P<0.05);试验组患者的药物副反应发生率为13.21%,略高于常规组患者的9.43%,差异无统计学意义(χ^(2)=0.712,P>0.05)。结论:卡前列素氨丁三醇能在一定程度上降低瘢痕子宫的产后出血风险,对改善患者子宫血流动力学参数、妊娠结局均有积极意义,联合应用此药未明显增强副反应发生风险,安全性较高。Objective:To observe the preventive and therapeutic effects of carboprost tromethamine on postpartum hemorrhage in scar uterus.Methods:106 patients with scar uterus admitted to the hospital from January 2022 and May 2023 were selected as the study subjects.They were randomly divided into conventional group(53 cases)and experimental group(53 cases)with computer randomization method.The conventional group received conventional treatment,while the experimental group received auxiliary treatment with carboprost tromethamine.The bleeding,hemostasis,uterine artery hemodynamic parameters,pregnancy outcomes and medication safety 3 h,6 h,and 9 h postpartum were compared between the two groups.Results:Under different treatment regimens,the bleeding volume scores of the experimental group 3 h,6 h,and 9 h postpartum were lower than those of the control group(t=3.259,3.775,2.437;P<0.05).The hemostasis time of the experimental group was lower than that of the conventional group,and the success rate of hemostasis was higher than that of the conventional group(t=12.357,χ^(2)=8.008,P<0.05).The S/D and PI of the experimental group were higher than those of the conventional group,while the RI was lower than that of the conventional group(t=4.242,6.410,4.198;P<0.05).The incidence of adverse pregnancy outcome in experimental group was 7.55%,which was lower than that in conventional group(22.64%),the difference was statistically significant(χ^(2)=8.884,P<0.05).The incidence of adverse drug reactions in experimental group was 13.21%,which was slightly higher than that in conventional group(9.43%),with no statistically significant difference(χ^(2)=0.712,P>0.05).Conclusion:Carboprost tromethamine can to some extent reduce the risk of postpartum hemorrhage in scarred uterus,and has positive significance in improving uterine hemodynamic parameters and pregnancy outcomes.Combined use of this drug does not significantly increase the risk of side effects,and its safety is relatively high.

关 键 词：瘢痕子宫 产后出血 卡前列素氨丁三醇 子宫血流动力学 妊娠结局 

分 类 号：R711[医药卫生—妇产科学]