中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值预测终末期肾病维持性血液透析患者预后的临床价值  

Prognostic Value of Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Predicting the Prognosis of MHD Patients with ESRD

作　　者：文静 刘妍 Wen Jing;Liu Yan(Department of Nephropathy and Rheumatology,The Central Hospital of Qianjiang,Qianjiang,Hubei,433199,China)

机构地区：[1]湖北省潜江市中心医院肾病风湿科,湖北潜江433199

出　　处：《黑龙江医学》2025年第6期691-693,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)预测终末期肾病维持性血液透析(MHD)患者预后的临床价值。方法:选取2020年1月—2022年10月于湖北省潜江市中心医院肾病风湿科行MHD治疗的225例终末期肾病患者作为研究对象,根据治疗1年内的预后情况将上述患者分为死亡组(n=42)和生存组(n=183)。比较两组患者临床资料相关指标。采用全自动生化分析仪检测所有患者外周血中性粒细胞、淋巴细胞及血小板等实验室指标,并计算NLR、PLR;采用logistic回归分析终末期肾病MHD患者死亡的影响因素;采用受试者工作特征(ROC)曲线法分析NLR、PLR联合检测对终末期肾病MHD患者死亡的预测价值。结果:死亡组患者NLR、PLR均高于生存组,差异均有统计学意义(t=9.142、9.325,P<0.05);logistic回归分析结果显示,NLR、PLR高水平均为终末期肾病MHD患者死亡的危险因素(OR=5.172、5.215,P<0.05);NLR、PLR联合检测预测终末期肾病MHD患者死亡的AUC、敏感度及特异度均优于单一指标。结论:NLR、PLR联合检测可明显提高预测终末期肾病MHD患者预后的敏感度和特异度。Objective:To explore the clinical value of NLR and PLR in predicting the prognosis of MHD patients with ESRD.Methods:According to the prognosis within one year of treatment,225 end-stage renal disease patients who underwent MHD treatment in the Nephrology and Rheumatology Department of the Central Hospital of Qianjiang from January 2020 to October 2022 were divided into a death group(n=42)and a survival group(n=183).The clinical data related indicators between the two groups were compared.The peripheral blood neutrophil,lymphocyte and platelets were measured by automatic biochemical analyzer,and NLR and PLR were calculated.The influencing factors of death in MHD patients with ESRD were analyzed by logistic regression equation.The predictive value of combined detection of NLR and PLR in MHD patients with ESRD was analyzed by ROC curve.Results:NLR and PLR in death group were higher than those in survival group,and the differences were statistically significant(t=9.142,9.325;P<0.05).Logistic regression analysis showed that high levels of NLR and PLR were risk factors for death in MHD patients with end-stage renal disease(OR=5.172,5.215;P<0.05).The AUC,sensitivity and specificity of combined NLR and PLR in predicting death of MHD patients with end-stage renal disease were better than that of single index.Conclusion:The combined detection of NLR and PLR can significantly improve the sensitivity and specificity in predicting the prognosis of MHD patients with ESRD.

关 键 词：中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 终末期肾病 维持性血液透析 

分 类 号：R692[医药卫生—泌尿科学]