乙型肝炎相关肝癌诊断对分期中肿瘤标志物与凝血4项指标检验作用  

Role of Tumor Markers and 4 Coagulation Indicators in the Diagnosis and Staging of Hepatitis B Related Liver Cancer

作　　者：穆权振 Mu Quanzhen(Laboratory Department,Shangqiu Municipal Hospital,Shangqiu,Henan,476000,China)

机构地区：[1]商丘市立医院检验科,河南商丘476000

出　　处：《黑龙江医学》2025年第6期701-703,共3页Heilongjiang Medical Journal

摘　　要：目的:探究乙型肝炎相关肝癌诊断对分期中肿瘤标志物与凝血4项指标检验作用。方法:选取2022年10月—2023年12月商丘市立医院收治的62例乙型肝炎相关肝癌患者作为观察组,另选取62例健康体检者作为对照组。两组受检者均进行肿瘤标志物与凝血4项指标检验。分析两组受检者相关指标。结果:观察组患者纤维蛋白原(FIB)低于对照组,血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化的部分凝血酶时间(APTT)均高于对照组,差异均有统计学意义(t=13.287、16.050、15.485、26.340,P<0.001)。观察组患者不同巴塞罗那(BCLC)分期中,A期PT、TT、APTT水平较B期、C~D期低,FIB水平较B期、C~D期高,C~D期PT、TT、APTT水平最高,FIB水平最低,差异均有统计学意义(t=26.599、15.971、58.225、45.474,P<0.001)。观察组患者血管内皮生长因子(VEGF)、甲胎蛋白(AFP)、岩藻糖苷酶(AFU)水平均高于对照组,差异均有统计学意义(t=39.823、68.587、34.590,P<0.001)。观察组患者不同BCLC分期中,A期AFP、AFU、VEGF水平均较B期、C~D期低,C~D期肿瘤标志物水平最高,差异均有统计学意义(F=268.404、158.898、75.412,P<0.001)。结论:肿瘤标志物与凝血4项指标均可用于乙型肝炎相关肝癌诊断与分期中检验作用,二者联合使用可提高诊断效能,早期准确诊断出疾病,便于及时进行治疗。Objective:To explore the role of tumor markers and 4 coagulation indexes in the diagnosis and staging of hepatitis B related liver cancer.Methods:62 patients with hepatitis B-related liver cancer admitted to the hospital from October 2022 to December 2023 were selected as the observation group,and 62 healthy subjects from October 2022 to December 2023 were selected as the control group.Tumor markers and blood clotting were tested in both groups.Relevant indicators were analyzed.Results:Prothrombin time(PT),Activeated partial thromboplasting time(APTT)and Thrombin time(TT)in the observation group were higher than those in the control group(t=13.287,16.050,15.485,26.340;P<0.001).Fibrinogen(FIB)was lower than that of control group.In different BCLC stages in the observation group,the levels of PT,TT and APTT in stage A were lower than those in stage B and C~D,and the levels of FIB were higher than those in stage B and C~D,and the levels of PT,TT and APTT in stage C~D were the highest,and the levels of FIB were the lowest(t=26.599,15.971,58.225,45.474;P<0.001).The levels of Vascular endothelial growth factor(VEGF),alpha-fetoprotein(AFP)and Fucosidase(AFU)in the observation group were higher than those in the control group(t=39.825,68.587,34.590;P<0.001).In different BCLC stages in the observation group,the levels of AFP,AFU and VEGF in stage A were lower than those in stage B and C~D,and the levels of tumor markers in stage C-D were the highest(F=75.412,158.898,75.412;P<0.001).Conclusion:Tumor markers and coagulation can all be used in the diagnosis and staging of hepatitis B-related liver cancer.The combination of the two can improve the diagnostic efficiency,early and accurate diagnosis of the disease;and facilitate timely treatment.

关 键 词：乙型肝炎相关肝癌 肿瘤标志物 凝血4项指标 

分 类 号：R512.62[医药卫生—内科学]