布地奈德福莫特罗联合常规疗法治疗阻塞性睡眠呼吸暂停综合征合并重度慢性阻塞性肺炎的效果分析  

Effect Analysis of Budesonide and Formoterol Combined with Conventional Therapy in Treatment of Obstructive Sleep Apnea Syndrome Complicated with Severe Chronic Obstructive Pneumonia

作　　者：阚海峰[1] Kan Haifeng(Department of Respiratory Medicine,The People's Hospital of Rugao,Nantong 226500,Jiangsu Province,China)

机构地区：[1]如皋市人民医院呼吸内科,江苏南通226500

出　　处：《中国社区医师》2025年第6期12-14,共3页Chinese Community Doctors

摘　　要：目的:探讨布地奈德福莫特罗联合常规疗法治疗阻塞性睡眠呼吸暂停综合征合并重度慢性阻塞性肺炎的效果。方法:将2022年1月—2023年12月如皋市人民医院呼吸内科收治的60例阻塞性睡眠呼吸暂停综合征合并重度慢性阻塞性肺炎患者随机分为对照组和吸入剂组,各30例。对照组给予呼吸支持、促排痰、抗感染等对症治疗,吸入剂组在对照组基础上采用布地奈德福莫特罗治疗。对比两组治疗效果。结果:治疗前,两组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和FEV1/FVC对比,差异无统计学意义(P>0.05);治疗后,两组FVC、FEV1和FEV1/FVC提高,且吸入剂组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组睡眠呼吸暂停低通气指数对比,差异无统计学意义(P>0.05);治疗后,两组睡眠呼吸暂停低通气指数降低,且吸入剂组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组6 min步行距离对比,差异无统计学意义(P>0.05);治疗后,两组6 min步行距离延长,且吸入剂组长于对照组,差异有统计学意义(P<0.05)。结论:布地奈德福莫特罗联合常规疗法治疗阻塞性睡眠呼吸暂停综合征合并重度慢性阻塞性肺炎的效果较好,可有效改善患者症状、运动耐力,提升其肺功能。Objective:To explore the effect of budesonide and formoterol combined with conventional therapy in treatment of obstructive sleep apnea syndrome complicated with severe chronic obstructive pneumonia.Methods:Sixty patients with obstructive sleep apnea syndrome complicated with severe chronic obstructive pneumonia admitted to Department of Respiratory Medicine at the People's Hospital of Rugao from January 2022 to December 2023 were randomly divided into a control group and an inhalant group,with 30 cases in each group.The control group received breathing support,sputum elimination,anti-infection and other symptomatic treatments,while the inhalant group received budesonide and formoterol treatment on the basis of control group.The treatment effects of the two groups were compared.Results:Before treatment,there was no statistically significant difference in forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1)and FEV1/FVC between the two groups(P>0.05).After treatment,the FVC,FEV1 and FEV1/FVC in the two groups increased,and these parameters in the inhalant group were higher than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the apnea-hypopnea index between the two groups(P>0.05).After treatment,the apnea-hypopnea index in the two groups decreased,and this parameter in the inhalant group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the 6-min walking distance between the two groups(P>0.05).After treatment,the 6-min walking distance in the two groups prolonged,and this parameter in the inhalant group was longer than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Budesonide and formoterol combined with conventional therapy has a good effect in the treatment of obstructive sleep apnea syndrome complicated with severe chronic obstru

关 键 词：布地奈德福莫特罗 阻塞性睡眠呼吸暂停综合征 重度慢性阻塞性肺炎 

分 类 号：R766[医药卫生—耳鼻咽喉科] R563[医药卫生—临床医学]