盐酸戊乙奎醚对嵌顿疝伴肠组织损伤患者自噬基因Beclin1 mRNA表达情况与血清乳酸脱氢酶水平的影响分析  

Analysis on Influence of Penehyclidine Hydrochloride on Autophagy Gene Beclin1 mRNA Expression and Serum Lactate Dehydrogenase Levels in Incarcerated Hernia Patients with Intestinal Tissue Injury

作　　者：武建斌 武国强 赵志英[2] 杨冬花 Wu Jianbin;Wu Guoqiang;Zhao Zhiying;Yang Donghua(Department of Anesthesiology,Ulanqab Central Hospital,Ulanqab 012000,Inner Mongolia Autonomous Region,China;College of Medical Technology and Anesthesiology,Baotou Medical College,Baotou 014040,Inner Mongolia Autonomous Region,China)

机构地区：[1]乌兰察布市中心医院麻醉科,内蒙古自治区乌兰察布012000 [2]包头医学院医学技术与麻醉学院,内蒙古自治区包头014040

出　　处：《中国社区医师》2025年第6期42-44,共3页Chinese Community Doctors

摘　　要：目的:分析盐酸戊乙奎醚对嵌顿疝伴肠组织损伤患者自噬基因Beclin1 mRNA表达情况与血清乳酸脱氢酶(LDH)水平的影响。方法:选取2021年1月—2022年12月乌兰察布市中心医院收治的自嗜嵌顿疝伴肠组织损伤患者60例作为研究对象,随机分为对照组与观察组,各30例。两组均接受手术治疗,术后,观察组静脉推注盐酸戊乙奎醚,对照组静脉推注生理盐水。比较两组自噬基因Beclin1 mRNA表达情况及血清LDH水平。结果:治疗前,两组自噬基因Beclin1 mRNA、LDH水平比较,差异无统计学意义(P>0.05);治疗后,观察组自噬基因Beclin1 mRNA、LDH水平低于治疗前及同期对照组,差异有统计学意义(P<0.05)。结论:盐酸戊乙奎醚能够抑制嵌顿疝伴肠组织损伤患者自噬基因Beclin1 mRNA表达,降低血清LDH水平。Objective:To analyze the influence of penehyclidine hydrochloride on autophagy gene Beclin1 mRNA expression and serum lactate dehydrogenase(LDH)levels in incarcerated hernia patients with intestinal tissue injury.Methods:A total of 60 incarcerated hernia patients with intestinal tissue injury admitted to Ulanqab Central Hospital from January 2021 to December 2022 were selected as the study subjects.They were randomly divided into control group and observation group,with 30 cases in each group.Both groups received surgical treatment.After surgery,the observation group received intravenous bolus injection of penehyclidine hydrochloride,and the control group received intravenous bolus injection of physiological saline.The autophagy gene Beclin1 mRNA expression and serum LDH levels were compared between the two groups.Results:Before treatment,there was no statistically significant difference in autophagy gene Beclin1 mRNA and LDH levels between the two groups(P>0.05).After treatment,the autophagy gene Beclin1 mRNA and LDH levels in the observation group were lower than those before treatment and those in the control group during the same period,and the difference was statistically significant(P<0.05).Conclusion:Penehyclidine hydrochloride can inhibit the autophagy gene Beclin1 mRNA expression and reduce the serum LDH levels in patients with incarcerated hernia and intestinal tissue injury.

关 键 词：盐酸戊乙奎醚 嵌顿疝 肠组织损伤 自噬基因Beclin1 mRNA 血清乳酸脱氢酶 

分 类 号：R614[医药卫生—麻醉学]