急性脑梗死患者阿替普酶静脉溶栓治疗后脑出血性转化的影响因素分析  

Analysis of Influencing Factors of Cerebral Hemorrhagic Transformation After Intravenous Thrombolysis Therapy with Ateplase in Patients with Acute Cerebral Infarction

作　　者：张琳 Zhang Lin(Department of Neurology,Shanxian Dongda Hospital,Heze 274300,Shandong Province,China)

机构地区：[1]菏泽市单县东大医院神经内科,山东菏泽274300

出　　处：《中国社区医师》2025年第6期66-68,共3页Chinese Community Doctors

摘　　要：目的:分析急性脑梗死患者阿替普酶静脉溶栓治疗后脑出血性转化的影响因素。方法:选取2023年10月—2024年10月菏泽市单县东大医院收治的急性脑梗死患者90例作为研究对象,患者均实施阿替普酶静脉溶栓治疗,根据患者治疗后是否出现脑出血性转化分为脑出血性转化组(n=20)与非脑出血性转化组(n=70)。比较两组相关资料,分析急性脑梗死患者阿替普酶静脉溶栓治疗后脑出血性转化的影响因素。结果:脑出血性转化组年龄大于非脑出血性转化组,收缩压、舒张压、神经功能评分、随机血糖及同型半胱氨酸水平高于非脑出血性转化组,尿酸、低密度脂蛋白胆固醇水平低于非脑出血性转化组(P<0.001)。年龄大、收缩压高、舒张压高、神经功能评分高、尿酸水平低、低密度脂蛋白胆固醇水平低、随机血糖高、同型半胱氨酸水平高是急性脑梗死患者阿替普酶静脉溶栓治疗后脑出血性转化的独立影响因素(P<0.05)。结论:急性脑梗死患者阿替普酶静脉溶栓治疗后脑出血性转化的影响因素较多,临床应根据患者具体情况实施针对性干预,减少脑出血性转化发生风险。Objective:To analyze the influencing factors of cerebral hemorrhagic transformation after intravenous thrombolysis therapy with ateplase in patients with acute cerebral infarction.Methods:A total of 90 patients with acute cerebral infarction admitted to Shanxian Dongda Hospital of Heze City from October 2023 to October 2024 were selected as the study subjects.All patients received intravenous thrombolysis therapy with alteplase.They were divided into cerebral hemorrhagic transformation group(n=20)and non-cerebral hemorrhagic transformation group(n=70)according to the presence/absence of cerebral hemorrhagic transformation after therapy.The relevant data of the two groups were compared and the influencing factors of cerebral hemorrhagic transformation after intravenous thrombolysis therapy with ateplase in patients with acute cerebral infarction were analyzed.Results:The age of the cerebral hemorrhagic transformation group was higher than that of the non-cerebral hemorrhagic transformation group,the systolic blood pressure,diastolic blood pressure,neurological function score,random blood glucose and homocysteine levels of the cerebral hemorrhagic transformation group were higher than those of the non-cerebral hemorrhagic transformation group,and the levels of uric acid and low-density lipoprotein cholesterol of the cerebral hemorrhagic transformation group were lower than those of the non-cerebral hemorrhagic transformation group(P<0.001).Older age,high systolic blood pressure,high diastolic blood pressure,high neurological function score,decreased uric acid level,low low-density lipoprotein cholesterol level,high random blood glucose,and elevated homocysteine level were the independent influencing factors of cerebral hemorrhagic transformation after intravenous thrombolysis therapy with ateplase in patients with acute cerebral infarction(P<0.05).Conclusion:There are many influencing factors of cerebral hemorrhagic transformation after intravenous thrombolysis therapy with ateplase in patients with acute cerebral

关 键 词：急性脑梗死 阿替普酶 静脉溶栓 脑出血性转化 

分 类 号：R543[医药卫生—心血管疾病]