孟鲁司特联合布地奈德在小儿持续性哮喘中的应用效果  

Application effect of Montelukast combined with Budesonide in pediatric persistent asthma

作　　者：何群 陈萍 HE Qun;CHEN Ping(Department of Pediatrics,Dongping County People’s Hospital,Shandong Province,Dongping 271500,China)

机构地区：[1]山东省东平县人民医院儿科,山东东平271500

出　　处：《妇儿健康导刊》2025年第5期104-107,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的 探讨孟鲁司特联合布地奈德在小儿持续性哮喘中的应用效果。方法 采取随机数字表法将东平县人民医院2020年1月至2022年12月收治的90例持续性哮喘患儿分为两组,每组各45例。对照组采用布地奈德治疗,观察组在对照组基础上联合孟鲁司特治疗。比较两组哮喘控制水平、肺功能及不良反应发生情况。结果 治疗3、6个月后,两组哮喘控制测试(ACT)评分较治疗前高,且观察组治疗3、6个月后的ACT评分均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组第1秒用力呼气容积(FEV_(1))、呼气流量峰值(PEF)均较治疗前高,且观察组FEV_(1)、PEF均高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 孟鲁司特联合布地奈德在小儿持续性哮喘中应用能够提高哮喘控制水平,改善肺功能。Objective To investigate the application effect of Montelukast combined with Budesonide in pediatric persistent asthma.Methods A total of 90 children with persistent asthma admitted to Dongping County People’s Hospital from January 2020 to December 2022 were divided into two groups using the random number table method,with 45 cases in each group.The control group was treated with Budesonide,while the observation group was treated with Montelukast on the basis of the control group.The asthma control levels,pulmonary function,and incidence of adverse reactions of the two groups were compared.Results After 3 and 6 months of treatment,the asthma control test(ACT)scores of both groups were higher than those before treatment,the ACT scores after 3 and 6 months of treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)in both groups were higher than those before treatment,the FEV1 and PEF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Montelukast Combined with Budesonide in the treatment of children with persistent asthma can improve the asthma control levels and pulmonary function.

关 键 词：孟鲁司特 布地奈德 小儿持续性哮喘 肺功能 

分 类 号：R725.6[医药卫生—儿科]