多囊卵巢综合征患者使用卵泡期长效长方案促排卵理想FSH启动剂量的预测模型  

Prediction model for ideal FSH starting dose in PCOS patients with follicular phase long-acting long protocol

作　　者：孔慧娟[1] 樊文倩 叶田[1] 杜霖青 郭艺红[1] KONG Huijuan;FAN Wenqian;YE Tian;DU Linqing;GUO Yihong(Reproductive Medicine Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450052

出　　处：《郑州大学学报(医学版)》2025年第2期177-180,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省高等学校重点科研项目计划(24A320033)。

摘　　要：目的:建立多囊卵巢综合征(PCOS)患者卵泡期长效长方案超促排卵理想FSH启动剂量的预测模型。方法:回顾性分析2022年1至12月于郑州大学第一附属医院生殖医学中心接受体外受精/卵胞浆内单精子显微注射助孕的956例PCOS患者的临床资料,按7∶3随机分配入训练集(668例)和验证集(288例)。采用广义线性模型建立FSH启动剂量的预测模型,使用Bland-Altman对预测启动剂量和实际剂量进行一致性检验。结果:FSH启动剂量与患者年龄、BMI、抗苗勒管激素(AMH)和窦卵泡数(AFC)有关,β(95%CI)分别为1.163(1.041~1.284)、3.784(3.588~3.980)、-3.329(-3.629~-3.028)和-1.090(-1.291~-0.890)。FSH启动剂量预测模型为FSH(IU)=38.110+1.163×年龄+3.784×BMI-3.329×AMH-1.090×AFC,Bland-Altman检验提示模型预测的启动剂量和实际剂量一致性较高,差值(95%CI)为-1.79(-31.86~28.28)IU。结论:本研究建立的FSH启动剂量预测模型直观、有效,具有一定的临床实用性。Aim:To construct a predictive model for the ideal starting dose of FSH in patients with polycystic ovary syndrome(PCOS)undergoing follicular phase long-acting long protocol.Methods:A retrospective analysis of clinical data from 956 PCOS patients who underwent in vitro fertilization or intracytoplasmic sperm injection at the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University between January 2022 and December 2022 was performed.Eligible patients were randomly allocated into a training set(70%,n=668)and a validation set(30%,n=288).A generalized linear regression model was employed to establish a predictive model for the FSH starting dose,and Bland-Altman analysis was performed to test the consistency between the predicted and actual FSH starting doses.Results:The FSH starting dose was related to patient′s age,BMI,anti-Mullerian hormone(AMH),and antral follicle count(AFC),andβ(95%CI)were 1.163(1.041-1.284),3.784(3.588-3.980),-3.329(-3.629--3.028)and-1.090(-1.291--0.890),respectively.The predictive model for the starting dose of FSH was FSH(IU)=38.110+1.163×age+3.784×BMI-3.329×AMH-1.090×AFC.Bland-Altman analysis indicated that the predicted starting dose by the model was essentially consistent with the actual starting dose,and the difference(95%CI)were-1.79(-31.86-28.28)IU.Conclusion:The predictive model for the FSH starting dose is intuitive and effective,and has certain clinical practicality.

关 键 词：卵泡期长效长方案 多囊卵巢综合征 FSH启动剂量 

分 类 号：R711.75[医药卫生—妇产科学]