阻塞性睡眠呼吸暂停与肥厚型心肌病心脏重构的关系  

Correlation between obstructive sleep apnea and cardiac remodeling in patients with hypertrophic cardiomyopathy

作　　者：潘崇 许浩博 翟关群 朱法胜 张体鹏 乔树宾[2] 崔锦钢[2] 袁建松[2] 胡奉环[2] 王娟[2] 王全河 PAN Chong;XU Haobo;ZHAI Guanqun;ZHU Fasheng;ZHANG Tipeng;QIAO Shubin;CUI Jingang;YUAN Jiansong;HU Fenghuan;WANG Juan;WANG Quanhe(Department of Cardiology,the Affiliated Zhengzhou Central Hospital,Zhengzhou University,Zhengzhou 450007;Coronary Heart Disease Center,Fuwai Hospital,National Center for Cardiovascular Diseases,Beijing Union Medical College,Chinese Academy of Medical Sciences,Beijing 100037)

机构地区：[1]郑州大学附属郑州中心医院心血管内科,郑州450007 [2]中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心,北京100037

出　　处：《郑州大学学报(医学版)》2025年第2期274-277,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：中国临床科学基金高水平医院项目(2022-1752)。

摘　　要：目的:探讨阻塞性睡眠呼吸暂停(OSA)与肥厚型心肌病(HCM)心脏重构的关系。方法:选取2010年2月至2019年1月在阜外医院确诊为HCM且接受睡眠监测的患者580例,记录一般资料、超声心动图、睡眠呼吸监测数据,采用Logistic回归分析睡眠呼吸监测数据与HCM患者心脏重构的关系。结果:Logistic回归分析显示,以性别、年龄、BMI、高血压、高脂血症、糖尿病、冠心病和吸烟史为调整因素,重度OSA、ln[呼吸暂停低通气指数(AHI)+1]、指动脉血氧饱和度(SaO_2)<90%占总睡眠时间(TST)百分比>10%、ln(SaO_2<90%占TST百分比+1)是HCM患者左心室扩大的危险因素,OR(95%CI)分别为2.480(1.220~5.043)、1.290(1.005~1.655)、2.198(1.233~3.917)、1.372(1.120~1.681)。结论:OSA严重程度及其相关指标与HCM患者心脏重构相关。Aim:To explore the correlation between obstructive sleep apnea(OSA)and cardiac remodeling in patients with hypertrophic cardiomyopathy(HCM).Methods:A total of 580 patients with HCM who underwent sleep monitoring at Fuwai Hospital from February 2010 to January 2019 were selected.General information,echocardiography,and polysomnographic parameters were recorded.Logistic regression analysis was used to determine the relationship between polysomnographic parameters and cardiac remodeling in patients with HCM.Results:Logistic regression analysis showed that severe OSA,ln[apnea-hypopnea index(AHI)+1],the percentage of total sleep time(TST)spent with oxygen saturation(SaO_2)<90%>10%,and ln(percentage of TST spent with SaO_2<90%+1)were risk factors for left ventricular enlargement in patients with HCM after adjusting for gender,age,BMI,hypertension,hyperlipidemia,diabetes mellitus,coronary artery disease and smoking history[OR(95%CI)were 2.480(1.220-5.043),1.290(1.005-1.655),2.198(1.233-3.917),1.372(1.120-1.681)].Conclusion:The severity of OSA and its associated indicators are correlated with cardiac remodeling in patients with HCM.

关 键 词：肥厚型心肌病 阻塞性睡眠呼吸暂停 心脏重构 左心室扩大 

分 类 号：R542.2[医药卫生—心血管疾病]