2型糖尿病患者血尿酸/高密度脂蛋白胆固醇比值与颈动脉粥样硬化相关性的研究  

Correlation between serum uric acid/high density lipoprotein cholesterol and carotid atherosclerosis inpatients with type 2 diabetes mellitus

作　　者：董崇周[1] 黄海泉[1] 章结楼[1] 夏莉莉[2] 周婉 叶山东 DONG Chongzhou;HUANG Haiquan;ZHANG Jielou(Department of Endocrinology,Tongling People's Hospital,Tongling 244000,China)

机构地区：[1]铜陵市人民医院内分泌科,244000 [2]铜陵市人民医院超声科,244000 [3]中国科学技术大学附属第一医院内分泌科

出　　处：《中国糖尿病杂志》2025年第2期86-89,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(82270863);安徽省卫健委科研项目(AHWJ2023BAc20076)。

摘　　要：目的 探讨T2DM患者血尿酸/HDL-C比值(UHR)与颈动脉粥样硬化(CAS)的相关性。方法 选取2021年11月至2023年3月于铜陵市人民医院内分泌科住院治疗的T2DM患者322例,根据是否合并CAS分为T2DM合并CAS(CAS,n=165)组和单纯T2DM(T2DM,n=157)组。比较两组一般资料、生化指标和UHR。结果 与T2DM组比较,CAS组年龄、SBP、TG、血肌酐(Scr)、胱抑素C、同型半胱氨酸(Hcy)、血尿酸和UHR升高(P<0.01),HDL-C和HbA_(1)c降低(P<0.05或P<0.01)。Pearson或Spearman相关分析显示,UHR与TG、Scr、Hcy呈正相关(P<0.01)。Logistic回归分析显示,年龄、SBP、UHR是T2DM患者发生CAS的影响因素。受试者工作特征曲线分析显示,UHR预测CAS的敏感度为82.40%,特异度为73.90%。结论 UHR是T2DM患者发生CAS的影响因素,对CAS有一定的预测价值。Objectivee To explore the correlation between serum uric acid/high density lipoprotein cholesterol(UHR)and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 322 patients with T2DM admitted to Department of Endocrinology,Tongling People's Hospital were enrolled in this study from November 2021 to March 2023.They were divided into CAS group(n=165)and T2DM group(n=157)according to whether accompanied with CAS.The medical history,physical examination,biochemical examination and UHR were compared between the two groups.Results Compared with T2DM group,the age,SBP,TG,Scr,Cys-C,Hcy,SUA and UHR in CAS group were increased(P<0.01),while HDL-C and HbA_(1)c were decreased(P<0.05 or P<0.01).Pearson or Spearman correlation analysis showed that TG,Scr and Hcy were correlated with UHR(P<O.O1).Logistic regression analysis showed that UHR,age and SBP were the independent risk factors of CAS in T2DM patients.ROC curve analysis showed that the sensitivity and specificity of UHR in predicting CAS were 82.40%and 73.90%.Conclusions UHR is the risk factor of CAS in T2DM patients and has a certain predictive value for CAS.

关 键 词：糖尿病 2型 血尿酸/高密度脂蛋白胆固醇比值 颈动脉粥样硬化 

分 类 号：R587.2[医药卫生—内分泌]