2型糖尿病患者血清C1q/肿瘤坏死因子相关蛋白12水平与颈动脉粥样硬化相关性的研究  

Correlation between serum CTRP12 and carotid atherosclerosis in patients with type 2 diabetes mellitus

作　　者：张晓玲 黄莹芝 ZHANG Xiaoling;HUANG Yingzhi(Department of Endocrinology,The Hospital of Suiri County,Huaibei 235000,China)

机构地区：[1]濉溪县医院内分泌科,淮北235000 [2]蚌埠医科大学第三附属医院内分泌科

出　　处：《中国糖尿病杂志》2025年第2期109-113,共5页Chinese Journal of Diabetes

基　　金：宿州市科技计划项目(SZSKJJZC047)。

摘　　要：目的 探讨T2DM患者血清C1q/肿瘤坏死因子相关蛋白12(CTRP12)与颈动脉粥样硬化(CAS)的相关性。方法 选取2023年1~12月于蚌埠医科大学第三附属医院内分泌科就诊的T2DM患者200例,根据是否合并CAS分为单纯T2DM组(n=94)和合并CAS(CAS,n=106)组,另选取同期体检健康者为正常对照(NC,n=50)组。ELISA测定血清CTRP12水平,比较各组CTRP12及基线资料。Pearson或Spearman相关分析血清CTRP12与其他指标的相关性。多元线性回归分析CTRP12影响因素。Logistic回归分析CAS影响因素。结果 三组DBP、HbA_(1)c、TC、LDL-C、IL-6依次升高(P<0.05),CTRP12依次降低(P<0.05)。T2DM、CAS组BMI、FPG、TG、胰岛素抵抗指数(HOMA-IR)高于NC组(P<0.05),HDL-C低于NC组(P<0.05),CAS组SBP高于NC、T2DM组(P<0.05)。Pearson或Spearman相关分析显示,血清CTRP12与BMI、SBP、DBP、FPG、HbA_(1)c、TC、TG、LDL-C、IL-6、HOMA-IR呈负相关(P<0.05),与HDL-C呈正相关(P<0.05)。多元线性回归分析显示,FPG、LDL-C及IL-6是CTRP12影响因素。Logistic回归分析显示,TC、HbA_(1)c及CTRP12是T2DM患者发生CAS的影响因素。结论 CTRP12与CAS密切相关,血清CTRP12水平降低是T2DM合并CAS的影响因素。Objective To evaluate the correlation between serum CTRP12 and carotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM).NMethodsA total of 200 T2DM patients from Bengbu Medical University Third Affilated Hospital were enrolled in this study and divided into T2DM group(n=94),CAS group(n=106).Healthy subjects were selected as normal control(NC,n=50)group.Serum CTRP12 level was determined by ELISA.CTRP12 and baseline indicators were compared among the groups.Relationship between CTRP12 and each biochemical index were evaluated by Pearson or Spearman analysis as appropriate.Multiple linear regression analysis was used to explore the influencing factors for CTRP12.Logistic regression analysis was used to explore the influencing factors for CAS.Results DBP,HbA_(1)c,TC,LDL-C and IL-6 in the three groups were increased successively(P<0.05),while CTRP12 were decreased successively(P<0.05).BMI,FPG,TG and HOMA-IR in T2DM and CAS groups were higher than those in NC group(P<0.05),HDL-C was lower than that in NC group(P<0.05),SBP in CAS group was higher than that in NC and T2DM groups(P<0.05).Pearson or Spearman correlation analysis showed that serum CTRP12 was negatively correlated with BMI,SBP,DBP,FPG,HbA_(1)c,TC,TG,LDL-C,IL-6 and HOMA-IR(P<0.05),and positively correlated with HDL-C(P<0.05).Multiple linear regression analysis showed that FPG,LDL-C and IL-6 were the influential factors for CTRP12.Logistic regression analysis showed that TC,HbA_(1)c and CTRP12 were risk factors for the occurrence of CAS in patients with T2DM.ConclusionssCTRP12 is closely related to CAS,and reduced serum CTRP12 level is an independent risk factor for T2DM with CAS.

关 键 词：C1q/肿瘤坏死因子相关蛋白12 糖尿病 2型 颈动脉粥样硬化 脂肪细胞因子 

分 类 号：R587.2[医药卫生—内分泌] R743.3[医药卫生—内科学]