肝脏瞬时弹性成像技术定量评价2型糖尿病合并代谢相关脂肪性肝病发病危险因素及相关性的研究  

Study on quantitative evaluation of risk factors and correlation of type 2 diabetes mellitus complicated with metabolic fatty liver disease by instantaneous elastic imaging of liver FibroScan

作　　者：杨振宇 韩敏娜 赵晨[2] 谭畅 陈婧[2] 李琳娜 杨馥铭 YANG Zhenyu;HAN Minna;ZHAO Chen(Department of Endocrinology,South China Hospital of Shenzhen University,Shenzhen 518116,China)

机构地区：[1]深圳大学附属华南医院内分泌科,518116 [2]哈尔滨市第一医院内分泌科

出　　处：《中国糖尿病杂志》2025年第2期131-135,共5页Chinese Journal of Diabetes

摘　　要：目的 应用肝脏瞬时弹性成像技术(Fibro Scan)定量检测T2DM患者肝脏脂肪指数(CAP)及肝脏硬度指数(LSM),分析T2DM合并代谢相关脂肪性肝病(MAFLD)发病的危险因素。方法 回顾性分析2017年8月至2020年11月哈尔滨市第一医院内分泌科诊治的T2DM患者258例,根据是否合并MAFLD分为单纯T2DM组(n=41)及合并MAFLD(MAFLD,n=217)组。采用Fibro Scan 502系统检测两组CAP、LSM,比较两组一般资料、TC、TG、LDL-C、HDL-C、FPG、Hb A1c、FC-P、FIns、谷草转氨酶(AST)、谷丙转氨酶、谷氨酰转肽酶等。结果 MAFLD组BMI、TG、FC-P、FIns、AST、CAP、LSM高于T2DM组(P<0.05)。Pearson相关分析显示,DM病程、TG、FC-P、LSM与CAP呈正相关(P<0.05),TG、AST、CAP与LSM呈正相关(P<0.05)。Logistic回归分析显示,BMI、TG、FC-P、CAP、LSM是T2DM合并MAFLD的危险因素。结论 BMI、TG、FC-P、CAP、LSM升高是T2DM合并MAFLD的危险因素,TG是CAP、LSM升高的共同因素,Fibro Scan检测CAP及LSM可定量揭示T2DM患者肝脏病变情况。Objectivee To quantitatively measure the liver fat content and liver fibrosis degree in patients with type 2 diabetes mellitus(T2DM)using liver transient elastography(FibroScan)and analyze the risk factors for metabolism-related fatty liver disease(MAFLD)M.IethodsA retrospective analysis was conducted on the clinical data of 258 patients with T2DM admitted to The Department of Endocrinology,Harbin First Hospital from August 2017 to November 2020.The patients were divided into the simple T2DM group(n=41)and the MAFLD(n=217)group based on whether they had MAFLD.Both groups were assessed using the FibroScan 502 system to measure liver fat content(CAP)and liver fibrosis degree(LSM).General information,TC,TG,LDL-C,HDL-C,FPG,HbAic,FC-P,FIns,and liver function(AST,ALT,GGT)were compared between the two groups.ResultsBMI,TG,FC-P,FIns,AST,CAP,and LSM were significantly higher in the MAFLD group than in the simple T2DM group(P<0.05).Pearson phase analysis showed that the DM duration,TG,FC-P and LSM were positively correlated with CAP(P<0.05),while TG,AST and CAP were positively correlated with LSM(P<0.05).Logistic regression analysis revealed that BMI,TG,FC-P,CAP,and LSM were risk factors for T2DM combined with MAFLD.Conclusionss Elevated BMI,TG,FC-P,CAP,and LSM are risk factors for the onset of T2DM combined with MAFLD.Additionally,TG is a common factor for the increase in CAP and LSM.FibroScan measurement of CAP and LSM values can quantitatively reveal the liver lesion status in patients with T2DM.

关 键 词：糖尿病 2型 肝脏瞬时弹性成像技术 代谢相关脂肪性肝病 危险因素 

分 类 号：R587.2[医药卫生—内分泌] R575.5[医药卫生—内科学]