中医体质学视角下的肿瘤与过敏反应联系探微  

Exploration on the relation between tumors and anaphylactic reaction from the perspective of traditional Chinese medicine constitution

作　　者：宗玉涵 王怀玉 周梦茹 江昊玥 金璐瑶 朱希焕 王济 ZONG Yuhan;WANG Huaiyu;ZHOU Mengru;JIANG Haoyue;JIN Luyao;ZHU Xihuan;WANG Ji(The Second School of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijingg100029,China;National Institute of TCM Constitution and Preventive Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Qi-huang Chinese Medicine School,Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510006 [2]北京中医药大学中医学院 [3]北京中医药大学国家中医体质与治未病研究院 [4]中国中医科学院中医基础理论研究所 [5]北京中医药大学岐黄学院

出　　处：《北京中医药大学学报》2025年第2期240-245,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(No.82174243);北京市自然科学基金面上项目(No.7242227);中央高校基本科研业务费专项资金“揭榜挂帅”重点项目(No.2023-JYB-JBZD-009);国家中医药管理局高水平中医药重点学科——中医体质学(No.zyyzdxk-2023251)。

摘　　要：肿瘤病因复杂,受宿主、环境等多种因素共同影响。过敏主要受辅助性T细胞2(Th2)免疫反应驱动,研究发现,Th2免疫反应与肿瘤联系密切,具体表现在Th2抗体、肿瘤内过敏相关效应细胞和介质,以及肿瘤免疫相关功能等方面,且这种内在交互机制会增加肿瘤和过敏这两类疾病临床诊治的复杂性和困难程度。过敏体质的形成由先天因素和后天因素共同铸就,其体质状态与过敏性疾病的发生、发展存在紧密关联。因此,本文拟从中医体质学视角,基于中医体质学“生命过程论”“形神构成论”“禀赋遗传论”“环境制约论”四大基本原理,从遗传因素与发病内因、炎性环境与功能调控、心理障碍与情志致病、年龄结构和发病风险4个方面探讨肿瘤与过敏反应的联系,并从体病相关的慢病防控角度探讨调理过敏体质对改善肿瘤患者过敏主观症状和客观指标的重要意义。The etiology of tumors is complex and influenced by multiple factors,including the host and environmental conditions.Allergy is primarily driven by the immune response of helper T cell 2(Th2).Research has shown that the Th2 immune response is closely related to tumors,which is specifically manifested through Th2 antibodies,allergy-related effector cells and mediators within the tumors,as well as tumor immune-related functions.This internal interaction mechanism will increase the complexity and challenges associated with the clinical diagnosis and treatment of tumors and allergy.The formation of allergic constitution is shaped by both congenital and acquired factors,and its physical state is closely linked to the occurrence and progression of allergic diseases.Therefore,this paper aims to explore the relationship between tumors and allergic reactions from the perspective of traditional Chinese medicine(TCM) constitution theory.Based on the four basic principles of the TCM constitution,including endowment inheritance theory,environment constraint theory,body-spirit composition theory,and life process theory,this exploration will focus on four aspects:genetic factors and internal disease causes,inflammatory environments and functional regulation,psychological disorders and emotional pathogenesis,as well as age structure and disease risk.Furthermore,from the perspective of constitution-disease relation of chronic disease prevention,this paper will discuss the significant importance of adjusting allergic constitution to improve both subjective symptoms and objective indicators of allergic reactions in tumor patients.

关 键 词：中医体质 过敏体质 过敏反应 肿瘤 过敏肿瘤学 

分 类 号：R273[医药卫生—中西医结合]