基于中断时间序列分析的综合防控措施对医院感染发生率变化趋势的影响  

The impact of comprehensive prevention and control measures on the trend of nosocomial infection rates based on interrupted time-series analysis

作　　者：徐榕徽 杨晓文[2] 陈利民 XU Ronghui;YANG Xiaowen;CHEN Limin(School of Management,Shanxi Medical University,Shanxi 030000 China;Shanxi Provincial People′s Hospital)

机构地区：[1]山西医科大学管理学院,山西030000 [2]山西省人民医院

出　　处：《护理研究》2025年第6期936-940,共5页Chinese Nursing Research

基　　金：山西省卫健委科研项目,编号:2021108。

摘　　要：目的:基于中断时间序列分析探究新型冠状病毒感染综合防控措施对医院感染发生率变化趋势的影响。方法:选取2018年2月—2022年1月在山西省某三级甲等综合医院住院的2301例医院感染病人为研究对象,将2018年2月—2020年1月定义为疫情防控前,2020年2月—2022年1月定义为疫情防控期,疫情防控前采用常规医院感染控制方法,疫情防控期采取综合防控措施。采用中断时间序列分析方法分析综合防控措施实施前后医院感染率的变化趋势。结果:分段线性回归模型显示,β_(1)=0.000,P=0.939;β_(2)=-0.032,P=0.773;β_(3)=-0.025,P=0.015。神经外科、重症监护室的β_(1)、β_(2)和β_(3)均无统计学意义(均P>0.05);血液科β_(1)、β_(2)均无统计学意义(P>0.05),但β_(3)有统计学意义(P=0.008);胃肠外科的β_(1)、β_(3)均有统计学意义(P<0.05),而β_(2)无统计学意义(P=0.141);神经内科β_(1)、β_(2)均有统计学意义(P<0.05),而β_(3)无统计学意义(P=0.271)。结论:新型冠状病毒感染综合防控措施对医院感染主要产生了长期效应,医院感染发生率逐步降低,但不同科室的医院感染受影响情况存在一定差异。Objective:To investigate the impact of comprehensive prevention and control measures for corona virus disease 2019 on the trend of nosocomial infection rates using interrupted time-series analysis.Methods:A total of 2301 patients with nosocomial infection from a tertiary grade A general hospital in Shanxi province were selected as subjects from February 2018 and January 2022.The period from February 2018 to January 2020 was defined as the pre-pandemic phase,and the period from February 2020 to January 2022 was defined as the pandemic control phase.The routine infection control measures was employed at the pre-pandemic phase,while comprehensive prevention and control measures for corona virus disease 2019 was employed at the pandemic control phase.Interrupted time-series analysis was used to evaluate trend of nosocomial infection rates before and after the implementation of comprehensive prevention and control measures.Results:The segmented linear regression model showed thatβ_(1)=0.000,P=0.939;β_(2)=-0.032,P=0.773;β_(3)=-0.025,P=0.015.There was no statistically significant differences(P>0.05)inβ_(1),β_(2) andβ_(3) for the neurosurgery department and ICU.There was no statistically significant(P>0.05)inβ_(1) andβ_(2) for the hematology department,but there was statistical significance(P=0.008)inβ_(3).There was statistically significant(P<0.05)inβ_(1) andβ_(3) for the gastrointestinal surgery,but there was no statistically significant(P=0.141)inβ_(2).There was statistically significant(P<0.05)inβ_(1) andβ_(2) for the neurology department,but there was no statistically significant(P=0.271)inβ_(3).Conclusions:Comprehensive prevention and control measures for corona virus disease 2019 exerted long-term effect on reducing nosocomial infection rates.The incidence of nosocomial infection is gradually decreasing,but variations existed across departments.

关 键 词：医院感染 新型冠状病毒感染 疫情防控 中断时间序列分析 防控措施 

分 类 号：R47[医药卫生—护理学]