基于凝血功能、血小板水平评估低分子肝素对复发性流产易栓症的治疗效果  

To Evaluate the Therapeutic Effect of Low Molecular Weight Heparin on Recurrent Abortion Susceptibility Based on Coagulation Function and Platelet Level

作　　者：张海涛 张启航 路琳君 Zhang Haitao;Zhang Qihang;Lu Linjun(Department of Medical Laboratory,General Hospital of PingCoal Shenma Medical Group Henan Pingdingshan 467000)

机构地区：[1]平煤神马医疗集团总医院医学检验科,河南平顶山467000

出　　处：《哈尔滨医药》2025年第1期4-7,共4页Harbin Medical Journal

摘　　要：目的探究凝血功能、血小板水平评估低分子肝素对复发性流产易栓症的治疗效果。方法纳入复发性流产易栓症患者116例,凭借盲选分组法将其分为对照组58例和观察组58例。对照组实施常规保胎治疗方案,观察组则在对照组的基础上增加低分子肝素进行联合治疗,均持续进行4周的治疗。比较两组凝血指标、血小板计数、不良妊娠结局和药物不良反应。结果治疗后患者的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)均升高,而纤维蛋白原(FIB)均降低,且观察组APTT、PT、TT明显高于对照组,而该组的FIB水平则较对照组更低(P<0.05)。治疗后患者血小板计数均降低,且观察组血小板计数相较于对照组显著降低(P<0.05)。不良妊娠结局方面,观察组总发生率显著低于对照组(P<0.05)。药物不良反应方面,观察组与对照组相比更低(P<0.05)。结论低分子肝素在复发性流产易栓症患者的应用中具有较好的效果,可改善患者的凝血功能,降低体内血小板计数和不良妊娠结局发生率,且具有较低的药物不良反应,值得推广并应用于临床治疗。Objective To judge the curative properties of low-molecule heparin(LMWH)on recurring abortion hemorrhage via seeking clot activity and the platelet count.Methods A aggregate of 116 recipients of frequent abortion embolism came to our unit were utilized and isolated under two sections:regulate(58 instances)and seeing(58 examples),utilising a blind selected separating tool.The placebo group began routine infant care rehabilitation,versus the observers underwent both therapies with low-MW heparin on an identical principles as the unaffected team,and proceeded being given chemotherapy for 4 weeks.The hemoglobin search,blood count,poor delivery results,and hazardous drug reply occurred in the two pairs.Results The initial result verified the same trend(P>0.05).Upon care,APTT,PT,and TT bumped although FIB sank.APTT(33.62±3.97)s,PT(13.37±0.75)s,and TT(15.49±0.78)were far more in the trial unit instead of the blank lab,whilst FIB(2.71±0.24)g/L was below.P<0.05.During remedy,all customers platelet activity slipped.The clinical arm had a far lower platelet numbers(231.58±18.06)×10^(9)/L versus the placebo cohort(P<0.05).The participant team had a notably lower risk for unfavorable birth(10.34%)relative to the placebo unit(25.86%,P<0.05).The trial sample had cheaper contrary drug reactions juxtaposed to the placebo cohort.Conclusion Low moles of histamine has an uplifting impact in the care of ongoing abortion bleeding folks,honing bleeding development,cutting platelet counts in the tissues and minimizing the chance of poor pregnancies,and putting minimal hurt drug action,proving it suitable of growth and consumption in hospitals.

关 键 词：凝血功能 血小板水平 低分子肝素 复发性流产 易栓症 

分 类 号：R714.21[医药卫生—妇产科学]