银杏二萜内酯葡胺注射液联合针灸对中风后偏瘫患者肢体功能恢复及血清Hcy、D-D影响  

Effect of Ginkgo Diterpene Lactone Meglumine Injection Combined with Acupuncture on Limb Function Recovery and Serum Hcy and D-D in Patients with Hemiplegia after Stroke

作　　者：李志运 宁群 张鹏 陈梅 张振红 王玉斌 Li Zhiyun;Ning Qun;Zhang Peng;Chen Mei;Zhang Zhenhong;Wang Yubin(Department of Neurology,the 988th Hospital of the Joint Logistic Support Force,Zhengzhou450000,Henan)

机构地区：[1]联勤保障部队第九八八医院神经内科,河南郑州450000

出　　处：《哈尔滨医药》2025年第1期112-115,共4页Harbin Medical Journal

摘　　要：目的探讨银杏二萜内酯葡胺注射液联合针灸对中风后偏瘫患者肢体功能恢复及血清同型半胱胺酸(Hcy)和D-二聚体(D-D)水平的影响。方法选取84例中风后偏瘫患者为受试对象,依照随机法分为药剂组与针药组各42例。药剂组患者采取常规治疗及银杏二萜内酯葡胺注射液施治,针药组患者在此基础上联合针灸施治。治疗后,对两组患者中医症候积分、肢体运动功能、日常自理能力、神经缺损情况进行比较,记录两组患者治疗前后的血液流变学指标、血清超敏C-反应蛋白(Hs-CRP)、Hcy、D-D水平并进行比较。结果治疗后,两组中医症状积分均呈现下降趋势,针药组下降趋势明显大于药剂组(P<0.05);上肢FMA评分、下肢FMA评分、MBI评分均显示出升高趋势,但针药组增加趋势大于药剂组(P<0.05);两组NIHSS评分、高切全血黏度、低切全血黏度、Fib、HCT、ESR水平、Hs-CRP、Hcy、D-D水平均呈现降低趋势,但针药组降低趋势均大于药剂组(P<0.05)。结论对中风后偏瘫患者采用银杏二萜内酯葡胺注射液联合针灸施治,可降低神经功能损伤,更快速恢复患者肢体功能,改善血液流变学并减轻炎症,对改善预后有益。Objective To investigate the effect of ginkgo diterpene lactone meglumine injection combined with acupuncture on limb function recovery and serum homocysteine(Hcy)and D-dimer(D-D)levels in patients with hemiplegia after stroke.Methods A total of 84 patients with hemiplegia after stroke were selected as subjects and randomLy divided into a drug group and a drug-acupuncture group with 42 cases in each group according to the enveloperandom method.Patients in the drug group were treated with conventional treatment and ginkgo diterpene lactone meglumine injection,and patients in the drug-acupuncture group were treated with acupuncture on this basis.The traditional Chinese medicine(TCM)syndrome scores,limb motor function[Fugl-Meyer Assessment Scale(FMA)],daily self-care ability[Modified Barthel Index(MBI)],and nerve defect[National Institutes of Health Stroke Scale(NIHSS)]of the two groups of patients after treatment were compared.The changes of hemorheological indexes[whole blood viscosity,fibrinogen(Fib),hematocrit(HCT),erythrocyte sedimentation rate(ESR)],high-sensitivity C-reactive protein(Hs-CRP),Hcy,and D-D levels of the two groups of patients before and after treatment were observed.Results After treatment,it was observed that the TCM syndrome scores of both groups decreased,but the decreasing trend in the drug-acupuncture group was more significant than that in the drug group(P<0.05);the upper-limb FMA score,lower-limb FMA score,and MBI score all showed an increasing trend,but the increasing trend in the drug-acupuncture group was greater than that in the drug group(P<0.05);the NIHSS score,high-shear whole-blood viscosity,low-shear whole-blood viscosity,Fib,HCT,ESR levels,Hs-CRP,Hcy,and D-D levels of the two groups all showed a decreasing trend,but the decreasing trend in the drug-acupuncture group was greater than that in the drug group(P≤0.05).Conclusion Ginkgo diterpene lactone meglumine injection combined with acupuncture treatment can reduce nerve function damage in patients with hemiplegia after stroke,

关 键 词：银杏二萜内酯葡胺注射液 针灸 中风 偏瘫患者 肢体功能 血清同型半胱氨酸、D-二聚体 

分 类 号：R255.2[医药卫生—中医内科学]