体力活动与前列腺癌发病风险:剂量反应Meta  

Physical Activity and Risk of Urinary System Cancer: Dose Response Meta

作　　者：穆萨·吾拉木 MUSA·Wulamu(Kashi University,College of Physical Education,Kashi Xinjiang,844000)

机构地区：[1]喀什大学体育学院,新疆喀什844000

出　　处：《湖北体育科技》2025年第2期48-53,共6页Hubei Sports Science

基　　金：新疆维吾尔自治区高校科技计划(XJEDU2021SY040)。

摘　　要：目的 探究体力活动与前列腺癌间的风险关系及剂量反应关系。方法 检索PubMed、Cochrane、EMbase、Web of Science、中国知网、万方、中国生物医学文献服务系统等数据库,运用Stata 15.0软件进行剂量反应Meta分析。结果 共纳入21项前瞻性队列研究或病例对照研究,包含3 586 004名受访者及51 326名前列腺癌患者。风险关系Meta分析结果表明:1)周TPA、MVPA分别降低24%[RR=0.76 (0.70~0.82)]、21%[RR=0.79(0.73~0.85)]的前列腺癌发病风险。2)TPA、MVPA对亚洲人群前列腺癌发病风险的影响效应更显著。3)TPA、MVPA与前列腺癌存在负相关对数剂量—反应关系,每周增加15 MET-h TPA可降低7%的前列腺癌[RR=0.93(0.88~0.98)]发病风险;每周增加10 MET-h MVPA可降低13%的前列腺癌[RR=0.87(0.83~0.91)]发病风险。4)前列腺癌发病的周TPA、周MVPA代谢当量任务小时数危险阈值分别为≥15 MET-h/w、≥10 MET-h/w。结论TPA、MVPA可能是前列腺癌的风险因素,但其独立性仍有待验证,未来仍需要前瞻性、大样本的研究进一步补充和验证本研究的发现。Objective To explore the risk relationship and dose-response relationship between physical activity and prostate cancer.Methods Retrieve relevant literature on the association between physical activity and prostate cancer risk published in databases such as PubMed,Cochrane Library,EMbase,Web of Science,China National Knowledge Infrastructure,Wanfang,and China Biomedical Literature Service System.Use Stata 15.0 software for meta-analysis and dose-response meta-analysis.Results A total of 21 prospective cohort study or case-control study were included,including 3,586,004 respondents and 51,326 prostate cancer patients.The meta-analysis results of risk relationship showed that:1)TPA and MVPA decreased the risk of prostate cancer by 24%[RR=0.76(0.70-0.82)]and 21%[RR=0.79(0.73-0.85)].2)TPA and MVPA have a more significant impact on the risk of prostate cancer in the Asian population.3)There was a negative correlation between TPA,MVPA,and prostate cancer in a logarithmic dose-response relationship.Increasing TPA by 15 MET-h per week could reduce the risk of prostate cancer by 7%[RR=0.93(0.88-0.98)].Adding 10 MET-h MVPA per week can reduce the risk of prostate cancer by 13%[RR=0.87(0.83~0.91)].4)The risk thresholds of weekly TPA and weekly MVPA Metabolic equivalent of task task hours for prostate cancer were≥15 MET-h/w and≥10 MET-h/w respectively.Conclusion TPA and MVPA may be risk factors for prostate cancer,but their independence still needs to be verified.In the future,prospective,large-scale studies are still needed to further supplement and validate the findings of this study.

关 键 词：中高强度体力活动 总体力活动 前列腺癌 风险关系 剂量反应Meta 

分 类 号：G804.2[文化科学—运动人体科学]