终末期肝病间充质干细胞归巢能力的影响因素及优化措施  

Influencing factors for the homing ability of mesenchymal stem cells in end-stage liver disease and optimization measures

作　　者：刘宇馨 张缭云[1] LIU Yuxin;ZHANG Liaoyun(Department of Infectious Diseases,The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院感染病科,太原030001

出　　处：《临床肝胆病杂志》2025年第3期561-567,共7页Journal of Clinical Hepatology

基　　金：山西省重点研发计划(201903D421056)。

摘　　要：间充质干细胞(MSC)因其强大的自我再生、旁分泌及免疫调节特性成为终末期肝病潜在的细胞治疗手段,为晚期肝病治疗提供了新的方向。然而,受损肝脏中炎症、氧化应激和缺氧等复杂微环境的影响,以及静脉注射后大部分MSC滞留在肺毛细血管中且缺乏足够的归巢受体或黏附分子,导致MSC在归巢过程中出现大量凋亡或坏死,只有少数细胞能够成功归巢至肝脏,极大限制了MSC的临床应用。为优化MSC的增殖、迁移及归巢能力,目前已开发多种方法,如预处理、基因修饰及纳米封装技术等。本文将重点阐述影响MSC归巢能力的因素及优化终末期肝病中MSC归巢的措施,并深入分析MSC归巢的机制,以期提高细胞植入效率,促进肝脏修复和再生,为MSC在终末期肝病治疗中的应用开辟新路径。Mesenchymal stem cells(MSCs)have emerged as a promising cellular therapy for end-stage liver disease(ESLD)due to their robust self-regenerative,paracrine,and immunomodulatory characteristics,providing new directions for the treatment of advanced liver disease.However,the clinical application of MSCs is significantly limited by the fact that only a small number of MSCs can reach the liver due to massive apoptosis or necrosis during the homing process caused by the influence of the complex microenvironment(inflammation,oxidative stress,and hypoxia)of the injured liver and the fact that a substantial proportion of MSCs become trapped in the pulmonary capillaries following intravenous administration with a lack of sufficient homing receptors or adhesion molecules.Various strategies have been developed to optimize the proliferation,migration,and homing abilities of MSCs,including preconditioning,gene modification,and nanoencapsulation technology.This article elaborates on the influencing factors for the homing ability of MSCs,the strategies to optimize their homing in ESLD,and the mechanism of the homing of MSCs,in order to improve cell transplantation efficiency,promote liver repair and regeneration,and pave the way for the application of MSCs in the treatment of ESLD.

关 键 词：终末期肝病 间质干细胞 归巢 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]