从中医辨证分型探讨中药复方防治抑郁症  

Study on Prevention and Treatment of Depressive Disorder by Different Chinese Herbal Compounds from Traditional Chinese Medicine Syndrome Differentiation

作　　者：陈玟璇 康舒悦 赵荻 荣立洋 史亚飞[2] 姚丽梅[3] 李伟荣[1] CHEN Wenxuan;KANG Shuyue;ZHAO Di;RONG Liyang;SHI Yafei;YAO Limei;LI Weirong(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;School of Basic Medical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;School of TCM Healthcare,Guangdong Food and Drug Vocational College,Guangzhou 510520 Guangdong,China)

机构地区：[1]广州中医药大学科技创新中心,广东广州510405 [2]广州中医药大学基础医学院,广东广州510006 [3]广东食品药品职业学院中医保健学院,广东广州510520

出　　处：《中药新药与临床药理》2025年第3期479-488,共10页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(82074505,82374547);广东省基础与应用基础研究基金项目(2023A1515011835,2022A1515010230,2022A1515220121)。

摘　　要：抑郁症是一种严重危害人类健康的精神疾病,其致病因素多,病理机制复杂。中药复方治疗抑郁症具有多成分、多靶点及个体化治疗的特点。根据中医辨证分型,抑郁症可分为六个类型,包括肝郁气滞型、肝郁脾虚型、肝郁化火型、心脾两虚型、心肾不交型和肾虚肝郁型。该文根据上述辨证分型系统整理近十年来治疗抑郁症的相关中药复方,并从药理研究和临床研究两个方面进行系统阐述。中药复方可通过调节炎症因子、神经递质、神经可塑性、信号传导通路、HPA轴等多途径发挥抗抑郁作用,在临床应用中显示出较好的治疗效果。Depression is a mental disease that seriously endangers human health,with many pathogenic factors and complex pathological mechanisms.The treatment of depressive disorders with Chinese herbal compounds has the characteristics of multi-component,multi-target and individualised treatment.According to the traditional Chinese medicine(TCM)syndrome differentiation and classification,depression can be divided into six types:liver depression and qi stagnation type,liver depression and spleen deficiency type,stagnated liver qi transforming in to fire type,heart-spleen deficiency type,incoordination between heart and kidney type and kidney deficiency liver depression type.Based on the above syndrome differentiation and classification,this article systematically collated the relevant Chinese herbal compounds for the treatment of depression in the past decade,and systematically elaborated them from both pharmacological and clinical studies.The TCM prescriptions can exert antidepressant effects by regulating inflammatory factors,neurotransmitters,neuroplasticity,signaling pathways,HPA axis and other pathways,and have shown ideal therapeutic effects in clinical applications.

关 键 词：中药复方 抑郁症 辨证分型 药理研究 临床研究 

分 类 号：R285.5[医药卫生—中药学] R285.6[医药卫生—中医学]