益气通络方对冠状动脉微血管疾病病人内皮细胞及炎性因子水平的影响  

Effects of Yiqitongluo Formula on Endothelial Cells and Inflammatory Factors in Patients with Coronary Microvascular Disease

作　　者：谢凤群 朱文 程洁[1] 冯其茂[1] XIE Fengqun;ZHU Wen;CHENG Jie;FENG Qimao(Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《中西医结合心脑血管病杂志》2025年第6期830-835,共6页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：上海市科学技术委员会科技支撑重点项目(No.19401972900);上海申康医院发展中心市级医院新兴前沿技术联合攻关项目(No.SHDC12019132);上海市卫健委临床专项(No.201940048);上海市进一步加快中医药事业发展三年行动计划项目[No.ZY(2018-2020)ZYBZ-18];上海市进一步加快中医药事业发展三年行动计划项目(No.B01B1);上海市中医医院未来计划中医传承发展项目(No.WLJH2021ZY-GZS002)。

摘　　要：目的:观察益气通络方对冠状动脉微血管疾病病人内皮细胞及炎性因子水平的影响。方法:选取2020年2月—2022年7月上海中医药大学附属市中医医院心内科住院收治和门诊就诊的冠状动脉微血管疾病病人98例,采用随机数字表法分为对照组和观察组,各49例。对照组采用常规西医治疗,观察组在常规西医治疗基础上联用益气通络方治疗,两组疗程均为3个月,随访6个月。比较两组中医证候积分、心绞痛症状及运动平板试验(Duke)评分、内皮细胞、炎性因子[内皮素-1(ET-1)、C反应蛋白(CRP)、白介素6(IL-6)、内皮型一氧化氮合酶(eNOS)、一氧化氮(NO)、超氧化物歧化酶(SOD)]、不良心血管事件、反复住院人次及不良反应。结果:与治疗前比较,观察组治疗后ET-1、CRP、IL-6水平均下降,eNOS、NO、SOD均升高,对照组治疗后ET-1、IL-6水平均下降,NO、SOD均升高,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组中医证候及心绞痛症状总有效率均高于对照组,差异均有统计学意义(P<0.05)。与治疗前比较,两组治疗后运动平板Duke评分均降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组反复住院发生率比较,差异有统计学意义(P<0.05)。结论:益气通络方联合常规西医治疗可改善冠状动脉微血管疾病病人内皮细胞、炎性因子水平及临床症状,一定程度降低反复住院率,安全性较高。Objective:To observe the effects of Yiqitongluo formula on endothelial cells and inflammatory factors in patients with coronary microvascular disease.Methods:Ninety-eight patients with coronary microvascular disease were divided into control group and observation group by random number table method,with 49 patients in each group.The patients of control group were treated with conventional western medicine,and the patients of observation group were treated with Yiqitongluo formula on the basis of conventional western medicine.The course of treatment in both groups was 3 months,and the follow-up was 6 months.Traditional Chinese medicine syndrome scores,angina pectoris symptoms and exercise treadmill test(Duke)scores,levels of endothelial cells and inflammatory factors[endothelin-1(ET-1),C-reactive protein(CRP),interleukin-6(IL-6),endothelial nitric oxide synthase(eNOS),nitric oxide(NO),superoxide dismutase(SOD)],adverse cardiovascular events,repeated hospitalizations,and adverse reactions were compared between two groups.Results:Compared with data before treatment,the levels of ET-1,CRP,and IL-6 were low,the levels of eNOS,NO and SOD were high in the observation group after treatment,and the levels of ET-1 and IL-6 were all low,NO and SOD were all high in the control group after treatment,while those in the observation group were superior to those in the control group,with statistical significance(P<0.05).The total effective rates of traditional Chinese medicine syndromes and angina pectoris in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Compared with data before treatment,the Duke score of exercise plate in both groups after treatment decreased,and that in the observation group was lower than that in the control group,with statistical significance(P<0.05).There was significant difference in the incidence of repeated hospitalization between the two groups(P<0.05).Conclusion:Yiqitongluo formula combined with conventional western medicin

关 键 词：冠状动脉微血管疾病 益气通络方 内皮细胞 炎性因子 中医证候 

分 类 号：R259[医药卫生—中西医结合]